Version 5.4
| Homo sapiens Gene: OSCAR | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-67991.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | OSCAR | ||||||||||||||||||
| Gene Name | osteoclast associated, immunoglobulin-like receptor | ||||||||||||||||||
| Synonyms | |||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000170909 | ||||||||||||||||||
| Encoded Proteins |
osteoclast associated, immunoglobulin-like receptor
osteoclast associated, immunoglobulin-like receptor
osteoclast associated, immunoglobulin-like receptor
osteoclast associated, immunoglobulin-like receptor
osteoclast associated, immunoglobulin-like receptor
osteoclast associated, immunoglobulin-like receptor
osteoclast associated, immunoglobulin-like receptor
osteoclast associated, immunoglobulin-like receptor
osteoclast associated, immunoglobulin-like receptor
osteoclast associated, immunoglobulin-like receptor
osteoclast associated, immunoglobulin-like receptor
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. This gene encodes an osteoclast-associated receptor (OSCAR), which is a member of the leukocyte receptor complex (LRC) protein family that plays critical roles in the regulation of both innate and adaptive immune responses. Different from the other LRC members, OSCAR expression is detected specifically in preosteoclasts or mature osteoclasts. OSCAR may be an important bone-specific regulator of osteoclast differentiation. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 19:54094668-54102692 | ||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||
| Band | q13.42 | ||||||||||||||||||
| Transcripts | |||||||||||||||||||
| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||
| NETPATH |
RANKL pathway
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| REACTOME | |||||||||||||||||||
| KEGG |
Osteoclast differentiation pathway
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| INOH | |||||||||||||||||||
| PID NCI | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | Q8IYS5 | ||||||||||||||||||
| TrEMBL | |||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 126014 | ||||||||||||||||||
| UniGene | Hs.347655 | ||||||||||||||||||
| RefSeq | NM_133168 NM_001282349 NM_001282350 NM_130771 NM_133169 NM_206818 | ||||||||||||||||||
| HUGO | HGNC:29960 | ||||||||||||||||||
| OMIM | 606862 | ||||||||||||||||||
| CCDS | CCDS12874 CCDS12873 CCDS12875 CCDS12876 CCDS62789 CCDS74444 | ||||||||||||||||||
| HPRD | 06035 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AC012314 AF251702 AF391162 AF391163 AF391164 AF474152 AF474153 AK091111 AK130199 AX746784 BC035023 | ||||||||||||||||||
| GenPept | AAH35023 AAL68495 AAL68496 AAL68497 AAM19095 AAQ05766 AAQ05767 BAC03586 | ||||||||||||||||||
| RNA Seq Atlas | 126014 | ||||||||||||||||||