Homo sapiens Gene: OSCAR
Summary
InnateDB Gene IDBG-67991.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol OSCAR
Gene Name osteoclast associated, immunoglobulin-like receptor
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000170909
Encoded Proteins
osteoclast associated, immunoglobulin-like receptor
osteoclast associated, immunoglobulin-like receptor
osteoclast associated, immunoglobulin-like receptor
osteoclast associated, immunoglobulin-like receptor
osteoclast associated, immunoglobulin-like receptor
osteoclast associated, immunoglobulin-like receptor
osteoclast associated, immunoglobulin-like receptor
osteoclast associated, immunoglobulin-like receptor
osteoclast associated, immunoglobulin-like receptor
osteoclast associated, immunoglobulin-like receptor
osteoclast associated, immunoglobulin-like receptor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. This gene encodes an osteoclast-associated receptor (OSCAR), which is a member of the leukocyte receptor complex (LRC) protein family that plays critical roles in the regulation of both innate and adaptive immune responses. Different from the other LRC members, OSCAR expression is detected specifically in preosteoclasts or mature osteoclasts. OSCAR may be an important bone-specific regulator of osteoclast differentiation. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:54094668-54102692
Strand Reverse strand
Band q13.42
Transcripts
ENST00000359649 ENSP00000352671
ENST00000284648 ENSP00000365808
ENST00000356532 ENSP00000348927
ENST00000358375 ENSP00000351145
ENST00000351806 ENSP00000304523
ENST00000391761 ENSP00000375641
ENST00000391760 ENSP00000375640
ENST00000616215 ENSP00000479628
ENST00000617140 ENSP00000484401
ENST00000611261 ENSP00000479089
ENST00000616447 ENSP00000483558
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
RANKL pathway
REACTOME
KEGG
Osteoclast differentiation pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q8IYS5
TrEMBL
UniProt Splice Variant
Entrez Gene 126014
UniGene Hs.347655
RefSeq NM_001282349 NM_206818 NM_133169 NM_133168 NM_001282350 NM_130771
HUGO HGNC:29960
OMIM 606862
CCDS CCDS74444 CCDS12876 CCDS62789 CCDS12873 CCDS12875 CCDS12874
HPRD 06035
IMGT
EMBL AC012314 AF251702 AF391162 AF391163 AF391164 AF474152 AF474153 AK091111 AK130199 AX746784 BC035023
GenPept AAH35023 AAL68495 AAL68496 AAL68497 AAM19095 AAQ05766 AAQ05767 BAC03586
RNA Seq Atlas 126014