Homo sapiens Gene: IL18RAP
Summary
InnateDB Gene IDBG-64252.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL18RAP
Gene Name interleukin 18 receptor accessory protein
Synonyms ACPL; CD218b; CDw218b; IL-18R-beta; IL-18RAcP; IL-18Rbeta; IL-1R-7; IL-1R7; IL-1RAcPL; IL18RB;
Species Homo sapiens
Ensembl Gene ENSG00000115607
Encoded Proteins
interleukin 18 receptor accessory protein
interleukin 18 receptor accessory protein
interleukin 18 receptor accessory protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is an accessory subunit of the heterodimeric receptor for IL18. This protein enhances the IL18 binding activity of IL18R1 (IL1RRP), a ligand binding subunit of IL18 receptor. The coexpression of IL18R1 and this protein is required for the activation of NF-kappaB and MAPK8 (JNK) in response to IL18. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is an accessory subunit of the heterodimeric receptor for interleukin 18 (IL18), a proinflammatory cytokine involved in inducing cell-mediated immunity. This protein enhances the IL18-binding activity of the IL18 receptor and plays a role in signaling by IL18. Mutations in this gene are associated with Crohn\'s disease and inflammatory bowel disease, and susceptibility to celiac disease and leprosy. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:102418689-102452565
Strand Forward strand
Band q12.1
Transcripts
ENST00000264260 ENSP00000264260
ENST00000409369 ENSP00000387201
ENST00000450855 ENSP00000389815
ENST00000497795
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 4 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005515 protein binding
Biological Process
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
Cellular Component
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Cytokine-cytokine receptor interaction pathway
INOH
PID BIOCARTA
PID NCI
IL12-mediated signaling events
IL12 signaling mediated by STAT4
IL23-mediated signaling events
Cross-References
SwissProt
TrEMBL Q3KPE8
UniProt Splice Variant
Entrez Gene 8807
UniGene Hs.158315
RefSeq NM_003853 XM_005264034
HUGO HGNC:5989
OMIM 604509
CCDS CCDS2061
HPRD 05147
IMGT
EMBL AC007248 AC007278 BC106764
GenPept AAI06765
RNA Seq Atlas 8807