Version 5.4
Mus musculus Gene: Il18rap
Summary
InnateDB Gene IDBG-148672.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Il18rap
Gene Name interleukin 18 receptor accessory protein
Synonyms AcPL; IL-18R-beta; IL-18RAcP; IL-18Rbeta; IL-1RAcPL
Species Mus musculus
Ensembl Gene ENSMUSG00000026068
Encoded Proteins
IDBP-148674
interleukin 18 receptor accessory protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Interleukin-18 (or interferon-gamma inducing factor) is a proinflammatory cytokine that induces cell-mediated immunity following microbial infection. This gene encodes a member of the interleukin-1 receptor family. The encoded protein is an accessory subunit of the receptor for interleukin-18 and mediates signaling through this cytokine. Mice lacking this gene exhibit a defective cell-mediated immune response. [provided by RefSeq, Jan 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:40515362-40551705
Strand Forward strand
Band B
Transcripts
ENSMUST00000027237 ENSMUSP00000027237
ENSMUST00000163057
ENSMUST00000159724
ENSMUST00000160468
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004908 interleukin-1 receptor activity
GO:0005515 protein binding
Biological Process
GO:0007165 signal transduction
GO:0019221 cytokine-mediated signaling pathway
Cellular Component
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000115607
View Gene Order
ENSBTAG00000033748
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04060
Cytokine-cytokine receptor interaction pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04060
Cytokine-cytokine receptor interaction pathway
INOH
PID NCI
il12_2pathway
IL12-mediated signaling events
il12_stat4pathway
IL12 signaling mediated by STAT4
il23pathway
IL23-mediated signaling events
Cross-References
SwissProt Q9Z2B1
TrEMBL Q0VBK3 Q3UV73
UniProt Splice Variant
Entrez Gene 16174
UniGene Mm.20466 Mm.392521 Mm.412920
RefSeq NM_010553 XM_006495708 XM_006495709 XM_006495712
OMIM
CCDS CCDS14912
HPRD
IMGT
MGI ID MGI:1338888
MGI Symbol Il18rap
EMBL AF077347 AK137541 BC120598 BC120600 CH466536
GenPept AAC72197 AAI20599 AAI20601 BAE23400 EDL14579
RNA Seq Atlas 16174

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca