Mus musculus Gene: Il18rap
Summary
InnateDB Gene IDBG-148672.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Il18rap
Gene Name interleukin 18 receptor accessory protein
Synonyms AcPL; IL-18R-beta; IL-18RAcP; IL-18Rbeta; IL-1RAcPL
Species Mus musculus
Ensembl Gene ENSMUSG00000026068
Encoded Proteins
interleukin 18 receptor accessory protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Interleukin-18 (or interferon-gamma inducing factor) is a proinflammatory cytokine that induces cell-mediated immunity following microbial infection. This gene encodes a member of the interleukin-1 receptor family. The encoded protein is an accessory subunit of the receptor for interleukin-18 and mediates signaling through this cytokine. Mice lacking this gene exhibit a defective cell-mediated immune response. [provided by RefSeq, Jan 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:40515362-40551705
Strand Forward strand
Band B
Transcripts
ENSMUST00000027237 ENSMUSP00000027237
ENSMUST00000163057
ENSMUST00000159724
ENSMUST00000160468
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004908 interleukin-1 receptor activity
GO:0005515 protein binding
Biological Process
GO:0007165 signal transduction
GO:0019221 cytokine-mediated signaling pathway
Cellular Component
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
KEGG
Cytokine-cytokine receptor interaction pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
Cytokine-cytokine receptor interaction pathway
INOH
PID NCI
IL12-mediated signaling events
IL12 signaling mediated by STAT4
IL23-mediated signaling events
Cross-References
SwissProt Q9Z2B1
TrEMBL Q0VBK3 Q3UV73
UniProt Splice Variant
Entrez Gene 16174
UniGene Mm.20466 Mm.392521 Mm.412920
RefSeq NM_010553 XM_006495708 XM_006495709 XM_006495712
OMIM
CCDS CCDS14912
HPRD
IMGT
MGI ID MGI:1338888
MGI Symbol Il18rap
EMBL AF077347 AK137541 BC120598 BC120600 CH466536
GenPept AAC72197 AAI20599 AAI20601 BAE23400 EDL14579
RNA Seq Atlas 16174