Version 5.4
Bos taurus Gene: TGM2
Summary
InnateDB Gene IDBG-642580.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TGM2
Gene Name Protein-glutamine gamma-glutamyltransferase 2
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000016208
Encoded Proteins
IDBP-695048
protein-glutamine gamma-glutamyltransferase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198959:
Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:67663138-67697607
Strand Reverse strand
Band
Transcripts
ENSBTAT00000021569 ENSBTAP00000021569
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 43 interaction(s) predicted by orthology.
Predicted by orthology
Total 43 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003810 protein-glutamine gamma-glutamyltransferase activity
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0016746 transferase activity, transferring acyl groups
GO:0046872 metal ion binding
Biological Process
GO:0018149 peptide cross-linking
GO:0032471 negative regulation of endoplasmic reticulum calcium ion concentration
GO:0043065 positive regulation of apoptotic process
GO:0043277 apoptotic cell clearance
GO:0045785 positive regulation of cell adhesion
GO:0051561 positive regulation of mitochondrial calcium ion concentration
GO:0060445 branching involved in salivary gland morphogenesis
GO:0060662 salivary gland cavitation
Cellular Component
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000198959
View Gene Order
ENSMUSG00000037820
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_25
FSH pathway
REACTOME
KEGG
hsa05016
Huntington's disease pathway
mmu05016
Huntington's disease pathway
INOH
PID NCI
txa2pathway
Thromboxane A2 receptor signaling
integrin1_pathway
Beta1 integrin cell surface interactions
integrin_a9b1_pathway
Alpha9 beta1 integrin signaling events
Cross-References
SwissProt P51176
TrEMBL
UniProt Splice Variant
Entrez Gene 281528
UniGene Bt.5401
RefSeq NM_177507
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC103290 X60686
GenPept AAI03291 CAA43097
RNA Seq Atlas 281528

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca