Homo sapiens Gene: TGM2
Summary
InnateDB Gene IDBG-74569.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TGM2
Gene Name transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)
Synonyms G-ALPHA-h; GNAH; HEL-S-45; TG2; TGC;
Species Homo sapiens
Ensembl Gene ENSG00000198959
Encoded Proteins
transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)
transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)
transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:38127387-38166578
Strand Reverse strand
Band q11.23
Transcripts
ENST00000361475 ENSP00000355330
ENST00000373403 ENSP00000362502
ENST00000453095 ENSP00000387642
ENST00000469269
ENST00000468262
ENST00000474777
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 82 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 82 [view]
Protein-Protein 82 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003810 protein-glutamine gamma-glutamyltransferase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0019904 protein domain specific binding
GO:0046872 metal ion binding
Biological Process
GO:0001974 blood vessel remodeling
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0018149 peptide cross-linking
GO:0018153 isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine
GO:0032471 negative regulation of endoplasmic reticulum calcium ion concentration
GO:0043065 positive regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043277 apoptotic cell clearance
GO:0045785 positive regulation of cell adhesion
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0050729 positive regulation of inflammatory response
GO:0051260 protein homooligomerization
GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
GO:0051561 positive regulation of mitochondrial calcium ion concentration
GO:0060445 branching involved in salivary gland morphogenesis
GO:0060662 salivary gland cavitation
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
FSH pathway
REACTOME
KEGG
Huntington's disease pathway
INOH
PID BIOCARTA
Phospholipase c delta in phospholipid associated cell signaling [Biocarta view]
PID NCI
Thromboxane A2 receptor signaling
Beta1 integrin cell surface interactions
Alpha9 beta1 integrin signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.517033
RefSeq NM_004613 NM_198951
HUGO
OMIM
CCDS CCDS13302
HPRD 01825
IMGT
EMBL
GenPept
RNA Seq Atlas