Version 5.4
Homo sapiens Gene: TGM2
Summary
InnateDB Gene IDBG-74569.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TGM2
Gene Name transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)
Synonyms G-ALPHA-h; GNAH; HEL-S-45; TG2; TGC
Species Homo sapiens
Ensembl Gene ENSG00000198959
Encoded Proteins
IDBP-74571
transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)
IDBP-74573
transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)
IDBP-374837
transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:38127387-38166578
Strand Reverse strand
Band q11.23
Transcripts
ENST00000361475 ENSP00000355330
ENST00000373403 ENSP00000362502
ENST00000453095 ENSP00000387642
ENST00000469269
ENST00000468262
ENST00000474777
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 82 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 82 [view]
Protein-Protein 82 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003810 protein-glutamine gamma-glutamyltransferase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0019904 protein domain specific binding
GO:0046872 metal ion binding
Biological Process
GO:0001974 blood vessel remodeling
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0018149 peptide cross-linking
GO:0018153 isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine
GO:0032471 negative regulation of endoplasmic reticulum calcium ion concentration
GO:0043065 positive regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043277 apoptotic cell clearance
GO:0045785 positive regulation of cell adhesion
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0050729 positive regulation of inflammatory response
GO:0051260 protein homooligomerization
GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
GO:0051561 positive regulation of mitochondrial calcium ion concentration
GO:0060445 branching involved in salivary gland morphogenesis
GO:0060662 salivary gland cavitation
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000037820
View Gene Order
ENSBTAG00000016208
Not yet available
Pathways
NETPATH
NetPath_25
FSH pathway
REACTOME
KEGG
hsa05016
Huntington's disease pathway
INOH
PID NCI
txa2pathway
Thromboxane A2 receptor signaling
integrin1_pathway
Beta1 integrin cell surface interactions
integrin_a9b1_pathway
Alpha9 beta1 integrin signaling events
Cross-References
SwissProt
TrEMBL A2A2A0
UniProt Splice Variant
Entrez Gene 7052
UniGene Hs.517033
RefSeq NM_004613 NM_198951
HUGO HGNC:11778
OMIM 190196
CCDS CCDS13302
HPRD 01825
IMGT
EMBL AL031651
GenPept
RNA Seq Atlas 7052

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca