InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: EPHA5

Summary

InnateDB Gene

IDBG-642651.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EPHA5

Gene Name

Uncharacterized protein

Synonyms

EPHA5

Species

Bos taurus

Ensembl Gene

ENSBTAG00000009438

Encoded Proteins

IDBP-695134

EPH receptor A5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000145242:
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Aug 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:82560093-82962887

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000039576

ENSBTAP00000039366

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005003	ephrin receptor activity
GO:0005004	GPI-linked ephrin receptor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007411	axon guidance
GO:0016310	phosphorylation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0021766	hippocampus development
GO:0032314	regulation of Rac GTPase activity
GO:0032956	regulation of actin cytoskeleton organization
GO:0048013	ephrin receptor signaling pathway
GO:0051964	negative regulation of synapse assembly
GO:0061178	regulation of insulin secretion involved in cellular response to glucose stimulus