InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Epha5

Summary

InnateDB Gene

IDBG-174718.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Epha5

Gene Name

Eph receptor A5

Synonyms

AI854630; AW125296; bsk; Cek7; Ehk1; Els1; Hek7; Rek7

Species

Mus musculus

Ensembl Gene

ENSMUSG00000029245

Encoded Proteins

IDBP-174720

Eph receptor A5

IDBP-253933

Eph receptor A5

IDBP-253935

Eph receptor A5

IDBP-253937

Eph receptor A5

IDBP-253939

Eph receptor A5

IDBP-253941

Eph receptor A5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000145242:
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Aug 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:84057791-84417382

Strand

Reverse strand

Band

Transcripts

ENSMUST00000053733	ENSMUSP00000060646
ENSMUST00000113406	ENSMUSP00000109033
ENSMUST00000113403	ENSMUSP00000109030
ENSMUST00000113401	ENSMUSP00000109028
ENSMUST00000113399	ENSMUSP00000109026
ENSMUST00000113398	ENSMUSP00000109025
ENSMUST00000154804
ENSMUST00000152573
ENSMUST00000155469
ENSMUST00000136775

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005003	ephrin receptor activity
GO:0005004	GPI-linked ephrin receptor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007411	axon guidance
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0019933	cAMP-mediated signaling
GO:0021766	hippocampus development
GO:0032314	regulation of Rac GTPase activity
GO:0032793	positive regulation of CREB transcription factor activity
GO:0032956	regulation of actin cytoskeleton organization
GO:0048013	ephrin receptor signaling pathway
GO:0051964	negative regulation of synapse assembly
GO:0061178	regulation of insulin secretion involved in cellular response to glucose stimulus

Cellular Component

GO:0005791	rough endoplasmic reticulum
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009897	external side of plasma membrane
GO:0016021	integral component of membrane
GO:0030424	axon
GO:0030425	dendrite
GO:0043025	neuronal cell body
GO:0048471	perinuclear region of cytoplasm