Version 5.4
Bos taurus Gene: BOK
Summary
InnateDB Gene IDBG-642666.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BOK
Gene Name bcl-2-related ovarian killer protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000008711
Encoded Proteins
IDBP-695146
BCL2-related ovarian killer
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000176720:
The protein encoded by this gene belongs to the BCL2 family, members of which form homo- or heterodimers, and act as anti- or proapoptotic regulators that are involved in a wide variety of cellular processes. Studies in rat show that this protein has restricted expression in reproductive tissues, interacts strongly with some antiapoptotic BCL2 proteins, not at all with proapoptotic BCL2 proteins, and induces apoptosis in transfected cells. Thus, this protein represents a proapoptotic member of the BCL2 family. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:121098866-121111324
Strand Forward strand
Band
Transcripts
ENSBTAT00000011478 ENSBTAP00000011478
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0008283 cell proliferation
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0042981 regulation of apoptotic process
GO:0051402 neuron apoptotic process
GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:1900119 positive regulation of execution phase of apoptosis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0031966 mitochondrial membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000176720
View Gene Order
ENSMUSG00000026278
View Gene Order
Cross-References
SwissProt
TrEMBL A6H6W7
UniProt Splice Variant
Entrez Gene 504851
UniGene Bt.29961
RefSeq NM_001098868
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC146025 DAAA02009538 DAAA02009539
GenPept AAI46026
RNA Seq Atlas 504851

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca