Bos taurus Gene: BOK
InnateDB Gene IDBG-642666.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BOK
Gene Name bcl-2-related ovarian killer protein
Species Bos taurus
Ensembl Gene ENSBTAG00000008711
Encoded Proteins
BCL2-related ovarian killer
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000176720:
The protein encoded by this gene belongs to the BCL2 family, members of which form homo- or heterodimers, and act as anti- or proapoptotic regulators that are involved in a wide variety of cellular processes. Studies in rat show that this protein has restricted expression in reproductive tissues, interacts strongly with some antiapoptotic BCL2 proteins, not at all with proapoptotic BCL2 proteins, and induces apoptosis in transfected cells. Thus, this protein represents a proapoptotic member of the BCL2 family. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:121098866-121111324
Strand Forward strand
ENSBTAT00000011478 ENSBTAP00000011478
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0008283 cell proliferation
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0042981 regulation of apoptotic process
GO:0051402 neuron apoptotic process
GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:1900119 positive regulation of execution phase of apoptosis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0031966 mitochondrial membrane
Homo sapiens
Mus musculus
Gene ID
Gene Order
UniProt Splice Variant
Entrez Gene 504851
UniGene Bt.29961
RefSeq NM_001098868
EMBL BC146025 DAAA02009538 DAAA02009539
GenPept AAI46026
RNA Seq Atlas 504851