Homo sapiens Gene: BOK
InnateDB Gene IDBG-85207.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BOK
Gene Name BCL2-related ovarian killer
Synonyms BCL2L9; BOKL
Species Homo sapiens
Ensembl Gene ENSG00000176720
Encoded Proteins
BCL2-related ovarian killer
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the BCL2 family, members of which form homo- or heterodimers, and act as anti- or proapoptotic regulators that are involved in a wide variety of cellular processes. Studies in rat show that this protein has restricted expression in reproductive tissues, interacts strongly with some antiapoptotic BCL2 proteins, not at all with proapoptotic BCL2 proteins, and induces apoptosis in transfected cells. Thus, this protein represents a proapoptotic member of the BCL2 family. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:241558721-241574138
Strand Forward strand
Band q37.3
ENST00000318407 ENSP00000314132
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
GO:0051400 BH domain binding
Biological Process
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007420 brain development
GO:0008283 cell proliferation
GO:0008584 male gonad development
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0042981 regulation of apoptotic process
GO:0043065 positive regulation of apoptotic process
GO:0048709 oligodendrocyte differentiation
GO:0051402 neuron apoptotic process
GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:1900119 positive regulation of execution phase of apoptosis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0031966 mitochondrial membrane
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
SwissProt Q9UMX3
TrEMBL A0A024R4A8 Q53NU8 Q53QM7
UniProt Splice Variant
Entrez Gene 666
UniGene Hs.293753
RefSeq NM_032515 XM_005247037
OMIM 605404
EMBL AC110299 AC133528 AF174487 BC006203 BT007272 CH471063
GenPept AAD51719 AAP35936 AAY14684 AAY14917 EAW71268 EAW71270 EAW71272 EAW71273 EAW71274
RNA Seq Atlas 666