Version 5.4
Bos taurus Gene: ATG4B
Summary
InnateDB Gene IDBG-642678.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ATG4B
Gene Name cysteine protease ATG4B
Synonyms Aut2b2
Species Bos taurus
Ensembl Gene ENSBTAG00000015401
Encoded Proteins
IDBP-695161
cysteine protease ATG4B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000168397:
Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:121162783-121171632
Strand Forward strand
Band
Transcripts
ENSBTAT00000020474 ENSBTAP00000020474
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004175 endopeptidase activity
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0008234 cysteine-type peptidase activity
GO:0016787 hydrolase activity
Biological Process
GO:0000045 autophagic vacuole assembly
GO:0006508 proteolysis
GO:0006810 transport
GO:0006914 autophagy
GO:0010508 positive regulation of autophagy
GO:0015031 protein transport
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000168397
View Gene Order
ENSMUSG00000026280
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04140
Regulation of autophagy pathway
mmu04140
Regulation of autophagy pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F1MJZ9
UniProt Splice Variant
Entrez Gene 408002
UniGene
RefSeq NM_001001170
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02009542
GenPept
RNA Seq Atlas 408002

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca