Version 5.4
Homo sapiens Gene: ATG4B
Summary
InnateDB Gene IDBG-85252.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ATG4B
Gene Name autophagy related 4B, cysteine peptidase
Synonyms APG4B; AUTL1
Species Homo sapiens
Ensembl Gene ENSG00000168397
Encoded Proteins
IDBP-85256
ATG4 autophagy related 4 homolog B (S. cerevisiae)
IDBP-227452
ATG4 autophagy related 4 homolog B (S. cerevisiae)
IDBP-227454
ATG4 autophagy related 4 homolog B (S. cerevisiae)
IDBP-292383
ATG4 autophagy related 4 homolog B (S. cerevisiae)
IDBP-295629
ATG4 autophagy related 4 homolog B (S. cerevisiae)
IDBP-292372
ATG4 autophagy related 4 homolog B (S. cerevisiae)
IDBP-389718
ATG4 autophagy related 4 homolog B (S. cerevisiae)
IDBP-389719
ATG4 autophagy related 4 homolog B (S. cerevisiae)
IDBP-389720
ATG4 autophagy related 4 homolog B (S. cerevisiae)
IDBP-389721
ATG4 autophagy related 4 homolog B (S. cerevisiae)
IDBP-389722
ATG4 autophagy related 4 homolog B (S. cerevisiae)
IDBP-389723
ATG4 autophagy related 4 homolog B (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:241637213-241673857
Strand Forward strand
Band q37.3
Transcripts
ENST00000344376 ENSP00000344960
ENST00000400772 ENSP00000383583
ENST00000400771 ENSP00000383582
ENST00000405546 ENSP00000383964
ENST00000404914 ENSP00000384259
ENST00000402096 ENSP00000384661
ENST00000419606 ENSP00000400050
ENST00000425239 ENSP00000409895
ENST00000415107 ENSP00000390597
ENST00000430617 ENSP00000407389
ENST00000429899 ENSP00000410526
ENST00000428861 ENSP00000404783
ENST00000491867
ENST00000494465
ENST00000483778
ENST00000479554
ENST00000475195
ENST00000465399
ENST00000468018
ENST00000482507
ENST00000493618
ENST00000460211
ENST00000479941
ENST00000475693
ENST00000494132
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 39 [view]
Protein-Protein 39 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004175 endopeptidase activity
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0000045 autophagic vacuole assembly
GO:0006508 proteolysis
GO:0006914 autophagy
GO:0010508 positive regulation of autophagy
GO:0015031 protein transport
GO:0045732 positive regulation of protein catabolic process
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026280
View Gene Order
ENSBTAG00000015401
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04140
Regulation of autophagy pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.283610
RefSeq NM_013325 NM_178326 XM_005246993 XM_005246996
HUGO
OMIM
CCDS CCDS46564 CCDS46565
HPRD 16499
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca