InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: NEU4

Summary

InnateDB Gene

IDBG-642698.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NEU4

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000014833

Encoded Proteins

sialidase 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000204099:
The protein encoded by this gene belongs to a family of glycohydrolytic enzymes, which remove terminal sialic acid residues from various sialo derivatives, such as glycoproteins, glycolipids, oligosaccharides, and gangliosides. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Nov 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:121271951-121274330

Strand

Forward strand

Band

Transcripts

ENSBTAT00000019755

ENSBTAP00000019755

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004308	exo-alpha-sialidase activity
GO:0005515	protein binding

Biological Process

GO:0006516	glycoprotein catabolic process
GO:0006689	ganglioside catabolic process
GO:0009313	oligosaccharide catabolic process

Cellular Component

GO:0005739	mitochondrion
GO:0005764	lysosome
GO:0019866	organelle inner membrane

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000204099

View Gene Order

ENSMUSG00000034000

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein pathway

Asparagine N-linked glycosylation pathway

Post-translational protein modification pathway

Synthesis of substrates in N-glycan biosythesis pathway

Sialic acid metabolism pathway

Metabolism of proteins pathway

Synthesis of substrates in N-glycan biosythesis pathway

Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein pathway

Glycosphingolipid metabolism pathway

Metabolism pathway

Sphingolipid metabolism pathway

Metabolism of proteins pathway

Post-translational protein modification pathway

Metabolism of lipids and lipoproteins pathway

Asparagine N-linked glycosylation pathway

Sialic acid metabolism pathway

KEGG

Sphingolipid metabolism pathway

Other glycan degradation pathway

Sphingolipid metabolism pathway

Other glycan degradation pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

E1BMN0

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

XM_002686626 XM_606439

HUGO

HGNC:21328

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02009544

GenPept

RNA Seq Atlas

528030

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1)

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca