Bos taurus Gene: DNASE2
Summary
InnateDB Gene IDBG-642909.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DNASE2
Gene Name deoxyribonuclease-2-alpha precursor
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000006082
Encoded Proteins
deoxyribonuclease-2-alpha precursor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Dnase2a is required for Tlr9 activation by bacterial genomic DNA.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000105612:
This gene encodes a member of the DNase family. The protein, located in the lysosome, hydrolyzes DNA under acidic conditions and mediates the breakdown of DNA during erythropoiesis and apoptosis. Two codominant alleles have been characterized, DNASE2*L (low activity) and DNASE2*H (high activity), that differ at one nucleotide in the promoter region. The DNASE2*H allele is represented in this record. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:13790587-13792998
Strand Forward strand
Band
Transcripts
ENSBTAT00000007993 ENSBTAP00000007993
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004531 deoxyribonuclease II activity
Biological Process
GO:0006259 DNA metabolic process
GO:0006308 DNA catabolic process
GO:0006309 apoptotic DNA fragmentation
GO:0030218 erythrocyte differentiation
Cellular Component
GO:0005622 intracellular
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
SSD Ortholog
Ortholog supports species divergence
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
trans-Golgi Network Vesicle Budding pathway
Clathrin derived vesicle budding pathway
Lysosome Vesicle Biogenesis pathway
Membrane Trafficking pathway
Membrane Trafficking pathway
Lysosome Vesicle Biogenesis pathway
trans-Golgi Network Vesicle Budding pathway
Clathrin derived vesicle budding pathway
KEGG
Lysosome pathway
Lysosome pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL F1MZ33
UniProt Splice Variant
Entrez Gene 282218
UniGene Bt.1240
RefSeq NM_001075127 XM_005208650
HUGO HGNC:2960
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02019382
GenPept
RNA Seq Atlas 282218
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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