Homo sapiens Gene: DNASE2
Summary
InnateDB Gene IDBG-31202.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DNASE2
Gene Name deoxyribonuclease II, lysosomal
Synonyms DNASE2A; DNL; DNL2;
Species Homo sapiens
Ensembl Gene ENSG00000105612
Encoded Proteins
deoxyribonuclease II, lysosomal
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Dnase2a is required for Tlr9 activation by bacterial genomic DNA.
Entrez Gene
Summary This gene encodes a member of the DNase family. The protein, located in the lysosome, hydrolyzes DNA under acidic conditions and mediates the breakdown of DNA during erythropoiesis and apoptosis. Two codominant alleles have been characterized, DNASE2*L (low activity) and DNASE2*H (high activity), that differ at one nucleotide in the promoter region. The DNASE2*H allele is represented in this record. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:12875211-12881468
Strand Reverse strand
Band p13.13
Transcripts
ENST00000222219 ENSP00000222219
ENST00000588777
ENST00000592506 ENSP00000466912
ENST00000586547
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0004520 endodeoxyribonuclease activity
GO:0004531 deoxyribonuclease II activity
Biological Process
GO:0000737 DNA catabolic process, endonucleolytic
GO:0006259 DNA metabolic process
GO:0006308 DNA catabolic process
GO:0006309 apoptotic DNA fragmentation
GO:0030218 erythrocyte differentiation
Cellular Component
GO:0005622 intracellular
GO:0005764 lysosome
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
trans-Golgi Network Vesicle Budding pathway
Clathrin derived vesicle budding pathway
Lysosome Vesicle Biogenesis pathway
Membrane Trafficking pathway
KEGG
Lysosome pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.118243
RefSeq NM_001375
HUGO
OMIM
CCDS CCDS12284
HPRD 00531
IMGT
EMBL
GenPept
RNA Seq Atlas