Version 5.4
Bos taurus Gene: AANAT
Summary
InnateDB Gene IDBG-643051.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AANAT
Gene Name serotonin N-acetyltransferase
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000014682
Encoded Proteins
IDBP-695571
serotonin N-acetyltransferase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. [provided by RefSeq, Feb 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:55917180-55918416
Strand Reverse strand
Band
Transcripts
ENSBTAT00000019543 ENSBTAP00000019543
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008080 N-acetyltransferase activity
Biological Process
GO:0008152 metabolic process
Cellular Component
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000129673
View Gene Order
ENSMUSG00000020804
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_15439
Serotonin and melatonin biosynthesis pathway
REACT_15513
Amine-derived hormones pathway
REACT_13
Metabolism of amino acids and derivatives pathway
REACT_111217
Metabolism pathway
REACT_188937
Metabolism pathway
REACT_232845
Metabolism of amino acids and derivatives pathway
REACT_218437
Serotonin and melatonin biosynthesis pathway
REACT_215158
Amine-derived hormones pathway
KEGG
hsa00380
Tryptophan metabolism pathway
mmu00380
Tryptophan metabolism pathway
INOH
INOH website
Tryptophan degradation pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.13120
RefSeq NM_177509
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca