InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Aanat

Summary

InnateDB Gene

IDBG-214486.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Aanat

Gene Name

arylalkylamine N-acetyltransferase

Synonyms

AA-NAT; Nat-2; Nat4; Snat

Species

Mus musculus

Ensembl Gene

ENSMUSG00000020804

Encoded Proteins

IDBP-214488

arylalkylamine N-acetyltransferase

IDBP-542458

arylalkylamine N-acetyltransferase

IDBP-535769

arylalkylamine N-acetyltransferase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:116586432-116597680

Strand

Forward strand

Band

Transcripts

ENSMUST00000021160	ENSMUSP00000021160
ENSMUST00000142978
ENSMUST00000153476	ENSMUSP00000122895
ENSMUST00000123507	ENSMUSP00000115999
ENSMUST00000132601

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004059	aralkylamine N-acetyltransferase activity
GO:0004060	arylamine N-acetyltransferase activity
GO:0008080	N-acetyltransferase activity
GO:0071889	14-3-3 protein binding

Biological Process

GO:0006474	N-terminal protein amino acid acetylation
GO:0007623	circadian rhythm
GO:0008152	metabolic process
GO:0009416	response to light stimulus
GO:0010043	response to zinc ion
GO:0014070	response to organic cyclic compound
GO:0030187	melatonin biosynthetic process
GO:0032868	response to insulin
GO:0034097	response to cytokine
GO:0034695	response to prostaglandin E
GO:0046688	response to copper ion
GO:0051412	response to corticosterone
GO:0051591	response to cAMP
GO:0051592	response to calcium ion
GO:0071320	cellular response to cAMP

Cellular Component

GO:0005737	cytoplasm
GO:0048471	perinuclear region of cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000129673

View Gene Order

ENSBTAG00000014682

Not yet available

Pathways

NETPATH

REACTOME

REACT_188937

Metabolism pathway

REACT_232845

Metabolism of amino acids and derivatives pathway

REACT_218437

Serotonin and melatonin biosynthesis pathway

REACT_215158

Amine-derived hormones pathway

KEGG

mmu00380

Tryptophan metabolism pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_15439

Serotonin and melatonin biosynthesis pathway

REACT_15513

Amine-derived hormones pathway

REACT_13

Metabolism of amino acids and derivatives pathway

REACT_111217

Metabolism pathway

KEGG

hsa00380

Tryptophan metabolism pathway

INOH

INOH website

Tryptophan degradation pathway

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.42233

RefSeq

NM_009591 XM_006531990

OMIM

CCDS

CCDS25671

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas