Mus musculus Gene: Aanat
Summary
InnateDB Gene IDBG-214486.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Aanat
Gene Name arylalkylamine N-acetyltransferase
Synonyms AA-NAT; Nat-2; Nat4; Snat;
Species Mus musculus
Ensembl Gene ENSMUSG00000020804
Encoded Proteins
arylalkylamine N-acetyltransferase
arylalkylamine N-acetyltransferase
arylalkylamine N-acetyltransferase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:116586432-116597680
Strand Forward strand
Band E2
Transcripts
ENSMUST00000021160 ENSMUSP00000021160
ENSMUST00000142978
ENSMUST00000153476 ENSMUSP00000122895
ENSMUST00000123507 ENSMUSP00000115999
ENSMUST00000132601
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004059 aralkylamine N-acetyltransferase activity
GO:0004060 arylamine N-acetyltransferase activity
GO:0008080 N-acetyltransferase activity
GO:0071889 14-3-3 protein binding
Biological Process
GO:0006474 N-terminal protein amino acid acetylation
GO:0007623 circadian rhythm
GO:0008152 metabolic process
GO:0009416 response to light stimulus
GO:0010043 response to zinc ion
GO:0014070 response to organic cyclic compound
GO:0030187 melatonin biosynthetic process
GO:0032868 response to insulin
GO:0034097 response to cytokine
GO:0034695 response to prostaglandin E
GO:0046688 response to copper ion
GO:0051412 response to corticosterone
GO:0051591 response to cAMP
GO:0051592 response to calcium ion
GO:0071320 cellular response to cAMP
Cellular Component
GO:0005737 cytoplasm
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Metabolism pathway
Metabolism of amino acids and derivatives pathway
Serotonin and melatonin biosynthesis pathway
Amine-derived hormones pathway
KEGG
Tryptophan metabolism pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Serotonin and melatonin biosynthesis pathway
Amine-derived hormones pathway
Metabolism of amino acids and derivatives pathway
Metabolism pathway
KEGG
Tryptophan metabolism pathway
INOH
Tryptophan degradation pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.42233
RefSeq NM_009591 XM_006531990
OMIM
CCDS CCDS25671
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas