InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: FLIP

Summary

InnateDB Gene

IDBG-643202.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FLIP

Gene Name

CASP8 and FADD-like apoptosis regulator

Synonyms

FLIP

Species

Bos taurus

Ensembl Gene

ENSBTAG00000010998

Encoded Proteins

IDBP-695744

CASP8 and FADD-like apoptosis regulator

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 21635783

[Homo sapiens] CFLAR confers protection against cytoplasmic dsRNA-mediated cell death and down-regulates IRF3- and NFkB-mediated gene expression. In addition, CFLAR also negatively regulates LPS-induced TLR4-signalling in endothelial cells and protects against TLR4-mediated apoptosis. (Demonstrated in murine model)

PMID 21635783

[Mus musculus] Cflar confers protection against cytoplasmic dsRNA-mediated cell death and down-regulates Irf3- and NFkB-mediated gene expression. In addition, Cflar also negatively regulates LPS-induced Tlr4-signalling in endothelial cells and protects against Tlr4-mediated apoptosis.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000003402:
The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8. Several transcript variants encoding different isoforms have been found for this gene, and partial evidence for several more variants exists. [provided by RefSeq, Feb 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:90139395-90172951

Strand

Forward strand

Band

Transcripts

ENSBTAT00000014607

ENSBTAP00000014607

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 54 interaction(s) predicted by orthology.

Predicted by orthology
Total	54 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0004197	cysteine-type endopeptidase activity
GO:0005515	protein binding
GO:0008047	enzyme activator activity
GO:0008234	cysteine-type peptidase activity
GO:0035877	death effector domain binding

Biological Process

GO:0006508	proteolysis
GO:0006915	apoptotic process
GO:0042981	regulation of apoptotic process
GO:0043085	positive regulation of catalytic activity
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0060544	regulation of necroptotic process
GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway