InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CFLAR

Summary

InnateDB Gene

IDBG-78386.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CFLAR

Gene Name

CASP8 and FADD-like apoptosis regulator

Synonyms

c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; CASH; CASP8AP1; Casper; CLARP; FLAME; FLAME-1; FLAME1; FLIP; I-FLICE; MRIT

Species

Homo sapiens

Ensembl Gene

ENSG00000003402

Encoded Proteins

IDBP-78388

CASP8 and FADD-like apoptosis regulator

IDBP-78390

CASP8 and FADD-like apoptosis regulator

IDBP-78394

CASP8 and FADD-like apoptosis regulator

IDBP-78398

CASP8 and FADD-like apoptosis regulator

IDBP-78400

CASP8 and FADD-like apoptosis regulator

IDBP-240138

CASP8 and FADD-like apoptosis regulator

IDBP-388302

CASP8 and FADD-like apoptosis regulator

IDBP-388305

CASP8 and FADD-like apoptosis regulator

IDBP-388306

CASP8 and FADD-like apoptosis regulator

IDBP-388307

CASP8 and FADD-like apoptosis regulator

IDBP-388308

CASP8 and FADD-like apoptosis regulator

IDBP-388309

CASP8 and FADD-like apoptosis regulator

IDBP-388310

CASP8 and FADD-like apoptosis regulator

IDBP-388311

CASP8 and FADD-like apoptosis regulator

IDBP-388313

CASP8 and FADD-like apoptosis regulator

IDBP-755617

IDBP-755496

IDBP-755560

IDBP-755540

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21635783

CFLAR confers protection against cytoplasmic dsRNA-mediated cell death and down-regulates IRF3- and NFkB-mediated gene expression. In addition, CFLAR also negatively regulates LPS-induced TLR4-signalling in endothelial cells and protects against TLR4-mediated apoptosis. (Demonstrated in murine model)

InnateDB Annotation from Orthologs

Summary

PMID 21635783

[Mus musculus] Cflar confers protection against cytoplasmic dsRNA-mediated cell death and down-regulates Irf3- and NFkB-mediated gene expression. In addition, Cflar also negatively regulates LPS-induced Tlr4-signalling in endothelial cells and protects against Tlr4-mediated apoptosis.

Entrez Gene

Summary

The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8. Several transcript variants encoding different isoforms have been found for this gene, and partial evidence for several more variants exists. [provided by RefSeq, Feb 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:201116104-201176687

Strand

Forward strand

Band

q33.1

Transcripts

ENST00000309955	ENSP00000312455
ENST00000341582	ENSP00000345807
ENST00000340870	ENSP00000339326
ENST00000342795	ENSP00000342809
ENST00000341222	ENSP00000339335
ENST00000395148	ENSP00000378580
ENST00000443227	ENSP00000413270
ENST00000441224	ENSP00000411897
ENST00000433445	ENSP00000391029
ENST00000423241	ENSP00000399420
ENST00000439154	ENSP00000398551
ENST00000425030	ENSP00000409570
ENST00000417748	ENSP00000412882
ENST00000440180	ENSP00000406775
ENST00000457277	ENSP00000411535
ENST00000490965
ENST00000461820
ENST00000461422
ENST00000494258	ENSP00000469608
ENST00000470178	ENSP00000471749
ENST00000462763	ENSP00000469917
ENST00000479953	ENSP00000471805
ENST00000460961
ENST00000474842
ENST00000470664

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 66 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	66 [view]
Protein-Protein	63 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0004197	cysteine-type endopeptidase activity
GO:0005123	death receptor binding
GO:0005515	protein binding
GO:0008047	enzyme activator activity
GO:0008234	cysteine-type peptidase activity
GO:0032403	protein complex binding
GO:0035877	death effector domain binding

Biological Process

GO:0006508	proteolysis
GO:0006915	apoptotic process
GO:0007519	skeletal muscle tissue development
GO:0014732	skeletal muscle atrophy
GO:0014842	regulation of satellite cell proliferation
GO:0014866	skeletal myofibril assembly
GO:0016032	viral process
GO:0042981	regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0043085	positive regulation of catalytic activity
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043403	skeletal muscle tissue regeneration
GO:0045087	innate immune response (InnateDB)
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0060544	regulation of necroptotic process
GO:0097190	apoptotic signaling pathway
GO:1901740	negative regulation of myoblast fusion
GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway
GO:2001239	regulation of extrinsic apoptotic signaling pathway in absence of ligand

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0031264	death-inducing signaling complex
GO:0031265	CD95 death-inducing signaling complex
GO:0045121	membrane raft
GO:0097342	ripoptosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000026031

View Gene Order

ENSBTAG00000010998

Not yet available

Pathways

NETPATH

NetPath_9

TNFalpha pathway

REACTOME

REACT_402

TRAIL signaling pathway

REACT_1059

Extrinsic Pathway for Apoptosis pathway

REACT_578

Apoptosis pathway

REACT_1619

Death Receptor Signalling pathway

KEGG

hsa04210

Apoptosis pathway

hsa05142

Chagas disease (American trypanosomiasis) pathway

INOH

INOH website

TNFR1 signaling pathway pathway

PID NCI

trail_pathway

TRAIL signaling pathway

myc_represspathway

Validated targets of C-MYC transcriptional repression

hivnefpathway

HIV-1 Nef: Negative effector of Fas and TNF-alpha

faspathway

FAS (CD95) signaling pathway

Cross-References

SwissProt

O15519

TrEMBL

C9J408 C9J4Q0 C9JSU3 C9JV51 M0R1A8

UniProt Splice Variant

Entrez Gene

8837

UniGene

Hs.609832

RefSeq

NM_001127184 NM_001127183 NM_001202515 NM_001202516 NM_001202517 NM_001202518 NM_001202519 NM_003879 XM_005246935 XM_005246936

HUGO

HGNC:1876

OMIM

603599

CCDS

CCDS46487 CCDS2337 CCDS56157 CCDS56158 CCDS59436

HPRD

04671

IMGT

EMBL

AB038972 AC007283 AF005774 AF005775 AF009616 AF009617 AF009618 AF009619 AF010127 AF015450 AF015451 AF015452 AF041458 AF041459 AF041460 AF041461 AF041462 AK289913 AK296036 AK315208 AK315924 BC001602 BT006751 CH471063 U85059 U97074 U97075 Y14039 Y14040

GenPept

AAB64110 AAB70909 AAB70910 AAB70911 AAB70912 AAB82648 AAB99790 AAB99791 AAB99792 AAB99793 AAB99794 AAC15825 AAC15826 AAC16439 AAC16440 AAC16441 AAC51622 AAC51623 AAH01602 AAP35397 AAY24290 BAB32551 BAB32552 BAF82602 BAG37645 BAG58802 BAH14295 CAA74366 CAA74367 EAW70237 EAW70244

RNA Seq Atlas

8837