Homo sapiens Gene: POLD3
Summary
InnateDB Gene IDBG-64335.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol POLD3
Gene Name polymerase (DNA-directed), delta 3, accessory subunit
Synonyms P66; P68; PPP1R128;
Species Homo sapiens
Ensembl Gene ENSG00000077514
Encoded Proteins
polymerase (DNA-directed), delta 3, accessory subunit
polymerase (DNA-directed), delta 3, accessory subunit
polymerase (DNA-directed), delta 3, accessory subunit
polymerase (DNA-directed), delta 3, accessory subunit
polymerase (DNA-directed), delta 3, accessory subunit
polymerase (DNA-directed), delta 3, accessory subunit
polymerase (DNA-directed), delta 3, accessory subunit
polymerase (DNA-directed), delta 3, accessory subunit
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes the 66-kDa subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein plays a role in regulating the activity of DNA polymerase delta through interactions with other subunits and the processivity cofactor proliferating cell nuclear antigen (PCNA). Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Mar 2012]
This gene encodes the 66-kDa subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3\' to 5\' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein plays a role in regulating the activity of DNA polymerase delta through interactions with other subunits and the processivity cofactor proliferating cell nuclear antigen (PCNA). Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Mar 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:74493851-74669117
Strand Forward strand
Band q13.4
Transcripts
ENST00000263681 ENSP00000263681
ENST00000528481 ENSP00000431239
ENST00000532784
ENST00000527458 ENSP00000432951
ENST00000532497 ENSP00000436018
ENST00000530511 ENSP00000432233
ENST00000531615 ENSP00000437231
ENST00000524752 ENSP00000432969
ENST00000530163
ENST00000532954 ENSP00000436781
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 29 [view]
Protein-Protein 29 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003887 DNA-directed DNA polymerase activity
GO:0005515 protein binding
Biological Process
GO:0000278 mitotic cell cycle
GO:0000722 telomere maintenance via recombination
GO:0000723 telomere maintenance
GO:0000731 DNA synthesis involved in DNA repair
GO:0006260 DNA replication
GO:0006261 DNA-dependent DNA replication
GO:0006271 DNA strand elongation involved in DNA replication
GO:0006281 DNA repair
GO:0006283 transcription-coupled nucleotide-excision repair
GO:0006284 base-excision repair
GO:0006289 nucleotide-excision repair
GO:0006297 nucleotide-excision repair, DNA gap filling
GO:0006298 mismatch repair
GO:0032201 telomere maintenance via semi-conservative replication
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005739 mitochondrion
GO:0043625 delta DNA polymerase complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
DNA Replication pathway
Repair synthesis for gap-filling by DNA polymerase in TC-NER pathway
Polymerase switching on the C-strand of the telomere pathway
Telomere C-strand (Lagging Strand) Synthesis pathway
Transcription-coupled NER (TC-NER) pathway
Synthesis of DNA pathway
Repair synthesis of patch ~27-30 bases long by DNA polymerase pathway
Removal of the Flap Intermediate from the C-strand pathway
Resolution of Abasic Sites (AP sites) pathway
Removal of the Flap Intermediate pathway
S Phase pathway
Chromosome Maintenance pathway
Polymerase switching pathway
Global Genomic NER (GG-NER) pathway
Telomere Maintenance pathway
Removal of DNA patch containing abasic residue pathway
Cell Cycle pathway
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) pathway
Base Excision Repair pathway
Processive synthesis on the lagging strand pathway
Cell Cycle, Mitotic pathway
DNA strand elongation pathway
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) pathway
Mismatch Repair pathway
Resolution of AP sites via the multiple-nucleotide patch replacement pathway pathway
Processive synthesis on the C-strand of the telomere pathway
Leading Strand Synthesis pathway
Extension of Telomeres pathway
Lagging Strand Synthesis pathway
Nucleotide Excision Repair pathway
Gap-filling DNA repair synthesis and ligation in GG-NER pathway
Gap-filling DNA repair synthesis and ligation in TC-NER pathway
DNA Repair pathway
KEGG
Purine metabolism pathway
Pyrimidine metabolism pathway
DNA replication pathway
Base excision repair pathway
Nucleotide excision repair pathway
Mismatch repair pathway
Homologous recombination pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q15054
TrEMBL A0A024R5M8 B4DMA6 E9PM91 E9PNC0 E9PRK3
UniProt Splice Variant
Entrez Gene 10714
UniGene Hs.82502
RefSeq NM_006591
HUGO HGNC:20932
OMIM 611415
CCDS CCDS8233
HPRD
IMGT
EMBL AK297375 AK316301 AP001104 AP001324 AP001372 BC108908 BC108909 CH471076 D26018
GenPept AAI08909 AAI08910 BAA05039 BAG59818 BAH14672 EAW74942 EAW74943
RNA Seq Atlas 10714