Version 5.4
Bos taurus Gene: BT.18482
Summary
InnateDB Gene IDBG-643366.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.18482
Gene Name dynamin-2
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000013362
Encoded Proteins
IDBP-695932
dynamin-2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000079805:
Dynamins represent one of the subfamilies of GTP-binding proteins. These proteins share considerable sequence similarity over the N-terminal portion of the molecule, which contains the GTPase domain. Dynamins are associated with microtubules. They have been implicated in cell processes such as endocytosis and cell motility, and in alterations of the membrane that accompany certain activities such as bone resorption by osteoclasts. Dynamins bind many proteins that bind actin and other cytoskeletal proteins. Dynamins can also self-assemble, a process that stimulates GTPase activity. Five alternatively spliced transcripts encoding different proteins have been described. Additional alternatively spliced transcripts may exist, but their full-length nature has not been determined. [provided by RefSeq, Jun 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:16465942-16523297
Strand Forward strand
Band
Transcripts
ENSBTAT00000036123 ENSBTAP00000035986
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 77 interaction(s) predicted by orthology.
Predicted by orthology
Total 77 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
Biological Process
GO:0006184 GTP catabolic process
GO:0006897 endocytosis
GO:0031623 receptor internalization
GO:0033572 transferrin transport
Cellular Component
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005874 microtubule
GO:0045211 postsynaptic membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000079805
View Gene Order
ENSMUSG00000033335
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_11
TCR pathway
NetPath_12
BCR pathway
NetPath_17
IL5 pathway
NetPath_56
Prolactin pathway
REACTOME
REACT_6894
Toll Like Receptor 4 (TLR4) Cascade pathway
REACT_121399
MHC class II antigen presentation pathway
REACT_12435
Retrograde neurotrophin signalling pathway
REACT_12541
NOSTRIN mediated eNOS trafficking pathway
REACT_11049
Formation of annular gap junctions pathway
REACT_11035
Gap junction degradation pathway
REACT_19287
Lysosome Vesicle Biogenesis pathway
REACT_19400
Golgi Associated Vesicle Biogenesis pathway
REACT_19187
Clathrin derived vesicle budding pathway
REACT_22365
Recycling pathway of L1 pathway
REACT_22205
L1CAM interactions pathway
REACT_111045
Developmental Biology pathway
REACT_11061
Signalling by NGF pathway
REACT_11235
trans-Golgi Network Vesicle Budding pathway
REACT_12389
eNOS activation and regulation pathway
REACT_6802
Innate Immune System pathway
REACT_12508
Metabolism of nitric oxide pathway
REACT_6966
Toll-Like Receptors Cascades pathway
REACT_18266
Axon guidance pathway
REACT_111102
Signal Transduction pathway
REACT_9411
Gap junction trafficking pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_111217
Metabolism pathway
REACT_9480
Gap junction trafficking and regulation pathway
REACT_11123
Membrane Trafficking pathway
REACT_239142
Innate Immune System pathway
REACT_224389
Gap junction trafficking and regulation pathway
REACT_204801
eNOS activation and regulation pathway
REACT_257923
Recycling pathway of L1 pathway
REACT_209837
Membrane Trafficking pathway
REACT_215995
NOSTRIN mediated eNOS trafficking pathway
REACT_220352
Formation of annular gap junctions pathway
REACT_188937
Metabolism pathway
REACT_231722
Lysosome Vesicle Biogenesis pathway
REACT_230745
Immune System pathway
REACT_232671
Golgi Associated Vesicle Biogenesis pathway
REACT_202778
Retrograde neurotrophin signalling pathway
REACT_196550
MHC class II antigen presentation pathway
REACT_209040
Gap junction degradation pathway
REACT_261444
Axon guidance pathway
REACT_251547
Toll-Like Receptors Cascades pathway
REACT_243409
trans-Golgi Network Vesicle Budding pathway
REACT_219680
L1CAM interactions pathway
REACT_234979
Clathrin derived vesicle budding pathway
REACT_248921
Signalling by NGF pathway
REACT_229531
Adaptive Immune System pathway
REACT_188576
Developmental Biology pathway
REACT_208364
Metabolism of nitric oxide pathway
REACT_237883
NGF signalling via TRKA from the plasma membrane pathway
REACT_217189
Gap junction trafficking pathway
REACT_188257
Signal Transduction pathway
REACT_246719
Toll Like Receptor 4 (TLR4) Cascade pathway
KEGG
hsa04666
Fc gamma R-mediated phagocytosis pathway
hsa04144
Endocytosis pathway
hsa05100
Bacterial invasion of epithelial cells pathway
mmu04666
Fc gamma R-mediated phagocytosis pathway
mmu04144
Endocytosis pathway
mmu05100
Bacterial invasion of epithelial cells pathway
INOH
PID NCI
vegfr1_2_pathway
Signaling events mediated by VEGFR1 and VEGFR2
syndecan_4_pathway
Syndecan-4-mediated signaling events
arf6_traffickingpathway
Arf6 trafficking events
pdgfrbpathway
PDGFR-beta signaling pathway
ajdiss_2pathway
Posttranslational regulation of adherens junction stability and dissassembly
Cross-References
SwissProt
TrEMBL F1MW91
UniProt Splice Variant
Entrez Gene 511691
UniGene Bt.18482
RefSeq NM_001099369
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02019474
GenPept
RNA Seq Atlas 511691

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca