InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: CTLA-4

Summary

InnateDB Gene

IDBG-643375.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CTLA-4

Gene Name

cytotoxic T-lymphocyte protein 4 precursor

Synonyms

CD152; CTLA-4

Species

Bos taurus

Ensembl Gene

ENSBTAG00000013170

Encoded Proteins

IDBP-695928

cytotoxic T-lymphocyte protein 4

IDBP-695930

cytotoxic T-lymphocyte protein 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 18824539

[Homo sapiens] CTLA4 blockade abrogates protection by regulatory T cells in a mouse model of microbe-induced innate immune-driven colitis.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163599:
This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:92490401-92495797

Strand

Forward strand

Band

Transcripts

ENSBTAT00000017527	ENSBTAP00000017527
ENSBTAT00000017528	ENSBTAP00000017528

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006955	immune response
GO:0006974	cellular response to DNA damage stimulus
GO:0030889	negative regulation of B cell proliferation
GO:0043065	positive regulation of apoptotic process
GO:0045590	negative regulation of regulatory T cell differentiation
GO:0050853	B cell receptor signaling pathway

Cellular Component

GO:0005794	Golgi apparatus
GO:0009897	external side of plasma membrane
GO:0016020	membrane
GO:0045334	clathrin-coated endocytic vesicle
GO:0048471	perinuclear region of cytoplasm