Version 5.4
Homo sapiens Gene: CTLA4
Summary
InnateDB Gene IDBG-79215.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CTLA4
Gene Name cytotoxic T-lymphocyte-associated protein 4
Synonyms CD; CD152; CELIAC3; CTLA-4; GRD4; GSE; IDDM12;
Species Homo sapiens
Ensembl Gene ENSG00000163599
Encoded Proteins
IDBP-79217
cytotoxic T-lymphocyte-associated protein 4
IDBP-79219
cytotoxic T-lymphocyte-associated protein 4
IDBP-388515
cytotoxic T-lymphocyte-associated protein 4
IDBP-476155
cytotoxic T-lymphocyte-associated protein 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 18824539
CTLA4 blockade abrogates protection by regulatory T cells in a mouse model of microbe-induced innate immune-driven colitis.
Entrez Gene
Summary This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:203867786-203873960
Strand Forward strand
Band q33.2
Transcripts
ENST00000302823 ENSP00000303939
ENST00000295854 ENSP00000295854
ENST00000427473 ENSP00000409707
ENST00000487393
ENST00000472206 ENSP00000417779
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 26 [view]
Protein-Protein 25 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006955 immune response
GO:0006974 cellular response to DNA damage stimulus
GO:0030889 negative regulation of B cell proliferation
GO:0031295 T cell costimulation
GO:0042130 negative regulation of T cell proliferation
GO:0043065 positive regulation of apoptotic process
GO:0045087 innate immune response (InnateDB)
GO:0045590 negative regulation of regulatory T cell differentiation
GO:0050777 negative regulation of immune response
GO:0050853 B cell receptor signaling pathway
Cellular Component
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009897 external side of plasma membrane
GO:0045334 clathrin-coated endocytic vesicle
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
ENSMUSG00000026011
View Gene Order
Ortholuge
SSD Ortholog
Ortholog supports species divergence
ENSBTAG00000013170
Not yet available
Ortholuge
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
NetPath_11
TCR pathway
REACTOME
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_19344
Costimulation by the CD28 family pathway
REACT_19405
CTLA4 inhibitory signaling pathway
KEGG
hsa04514
Cell adhesion molecules (CAMs) pathway
hsa04660
T cell receptor signaling pathway pathway
hsa05320
Autoimmune thyroid disease pathway
INOH
PID BIOCARTA
100193
The co-stimulatory signal during t-cell activation [Biocarta view]
PID NCI
nfat_tfpathway
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
Cross-References
SwissProt P16410
TrEMBL E9L3G0 E9L3G1 E9L3G3 Q0Q5F1
UniProt Splice Variant
Entrez Gene 1493
UniGene Hs.247824
RefSeq NM_001037631 NM_005214
HUGO HGNC:2505
OMIM 123890
CCDS CCDS2362 CCDS42803
HPRD 00474
IMGT
EMBL AC010138 AF142144 AF411058 AF414120 AH002733 AY792514 AY999702 BC074842 BC074893 DQ357942 DQ534199 DQ785106 HM545121 HM545124 HM545125 HM545126 L15006 M74363 U90273
GenPept AAA52127 AAA52773 AAB59385 AAD00698 AAF02499 AAH74842 AAH74893 AAL07473 AAL40932 AAV66331 AAX93176 AAY00166 ABC67470 ABG78999 ABG85285 ADV60197 ADV60198 ADV60199 ADV60200
RNA Seq Atlas 1493

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca