Bos taurus Gene: CRYGB
InnateDB Gene IDBG-643506.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CRYGB
Gene Name Gamma-crystallin B
Species Bos taurus
Ensembl Gene ENSBTAG00000021770
Encoded Proteins
Gamma-crystallin B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000182187:
Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Gamma-crystallins are a homogeneous group of highly symmetrical, monomeric proteins typically lacking connecting peptides and terminal extensions. They are differentially regulated after early development. Four gamma-crystallin genes (gamma-A through gamma-D) and three pseudogenes (gamma-E, gamma-F, gamma-G) are tandemly organized in a genomic segment as a gene cluster. Whether due to aging or mutations in specific genes, gamma-crystallins have been involved in cataract formation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:96848292-96850508
Strand Reverse strand
ENSBTAT00000009553 ENSBTAP00000009553
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005212 structural constituent of eye lens
Biological Process
GO:0001654 eye development
GO:0002088 lens development in camera-type eye
GO:0070307 lens fiber cell development
GO:0070309 lens fiber cell morphogenesis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Homo sapiens
Mus musculus
Gene ID
Gene Order
SwissProt P02526
UniProt Splice Variant
Entrez Gene 281720
UniGene Bt.399
RefSeq NM_001013594
EMBL EF208024 M16894 X01036
GenPept AAA30476 ABM97504 CAA25518
RNA Seq Atlas 281720