Version 5.4
Homo sapiens Gene: CRYGB
Summary
InnateDB Gene IDBG-79705.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CRYGB
Gene Name crystallin, gamma B
Synonyms CRYG2; CTRCT39
Species Homo sapiens
Ensembl Gene ENSG00000182187
Encoded Proteins
IDBP-79707
crystallin, gamma B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Gamma-crystallins are a homogeneous group of highly symmetrical, monomeric proteins typically lacking connecting peptides and terminal extensions. They are differentially regulated after early development. Four gamma-crystallin genes (gamma-A through gamma-D) and three pseudogenes (gamma-E, gamma-F, gamma-G) are tandemly organized in a genomic segment as a gene cluster. Whether due to aging or mutations in specific genes, gamma-crystallins have been involved in cataract formation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:208142573-208146168
Strand Reverse strand
Band q33.3
Transcripts
ENST00000260988 ENSP00000260988
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005212 structural constituent of eye lens
Biological Process
GO:0001654 eye development
GO:0002088 lens development in camera-type eye
GO:0007601 visual perception
GO:0070307 lens fiber cell development
GO:0070309 lens fiber cell morphogenesis
Cellular Component
GO:0005575 cellular_component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000073658
View Gene Order
ENSBTAG00000021770
Not yet available
Cross-References
SwissProt P07316
TrEMBL
UniProt Splice Variant
Entrez Gene 1419
UniGene Hs.248102
RefSeq NM_005210
HUGO HGNC:2409
OMIM 123670
CCDS CCDS2380
HPRD
IMGT
EMBL AC016697 BC074944 BC074945 BC117384 BC117388 M11970 M11971 M19364
GenPept AAA52109 AAA52113 AAH74944 AAH74945 AAI17385 AAI17389 AAX93219
RNA Seq Atlas 1419

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca