InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ADD1

Summary

InnateDB Gene

IDBG-643653.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADD1

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000021128

Encoded Proteins

IDBP-696259

adducin 1 (alpha)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000087274:
Adducins are a family of cytoskeleton proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha- and gamma-adducins are ubiquitously expressed. In contrast, beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:107929464-108018486

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000028152

ENSBTAP00000028152

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005198	structural molecule activity
GO:0008134	transcription factor binding
GO:0030507	spectrin binding
GO:0042803	protein homodimerization activity
GO:0044822	poly(A) RNA binding
GO:0046982	protein heterodimerization activity
GO:0051015	actin filament binding

Biological Process

GO:0000902	cell morphogenesis
GO:0001701	in utero embryonic development
GO:0006884	cell volume homeostasis
GO:0020027	hemoglobin metabolic process
GO:0030218	erythrocyte differentiation
GO:0032092	positive regulation of protein binding
GO:0035264	multicellular organism growth
GO:0048873	homeostasis of number of cells within a tissue
GO:0051016	barbed-end actin filament capping
GO:0051017	actin filament bundle assembly

Cellular Component

GO:0005634	nucleus
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0008290	F-actin capping protein complex
GO:0016020	membrane
GO:0045111	intermediate filament cytoskeleton