InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ADD1

Summary

InnateDB Gene

IDBG-7701.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADD1

Gene Name

adducin 1 (alpha)

Synonyms

ADDA

Species

Homo sapiens

Ensembl Gene

ENSG00000087274

Encoded Proteins

IDBP-7703

adducin 1 (alpha)

IDBP-7705

adducin 1 (alpha)

IDBP-233767

adducin 1 (alpha)

IDBP-233769

adducin 1 (alpha)

IDBP-233773

adducin 1 (alpha)

IDBP-361138

adducin 1 (alpha)

IDBP-476729

adducin 1 (alpha)

IDBP-480229

adducin 1 (alpha)

IDBP-484350

adducin 1 (alpha)

IDBP-474714

adducin 1 (alpha)

IDBP-478379

adducin 1 (alpha)

IDBP-479027

adducin 1 (alpha)

IDBP-602428

adducin 1 (alpha)

IDBP-592698

adducin 1 (alpha)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Adducins are a family of cytoskeleton proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha- and gamma-adducins are ubiquitously expressed. In contrast, beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:2843857-2930076

Strand

Forward strand

Band

p16.3

Transcripts

ENST00000264758	ENSP00000264758
ENST00000355842	ENSP00000348100
ENST00000374281
ENST00000398129	ENSP00000381197
ENST00000398125	ENSP00000381193
ENST00000398123	ENSP00000381191
ENST00000446856	ENSP00000399828
ENST00000508684
ENST00000510101	ENSP00000425703
ENST00000511797	ENSP00000421918
ENST00000503455	ENSP00000423024
ENST00000509039
ENST00000508277	ENSP00000426700
ENST00000503169
ENST00000513328	ENSP00000421907
ENST00000506157
ENST00000514940	ENSP00000424143
ENST00000513762
ENST00000503062
ENST00000539108
ENST00000540541
ENST00000534870
ENST00000536078
ENST00000541051
ENST00000536424	ENSP00000438069
ENST00000539149
ENST00000541843	ENSP00000441388
ENST00000538860

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	32 [view]
Protein-Protein	31 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005198	structural molecule activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0008134	transcription factor binding
GO:0030507	spectrin binding
GO:0042608	T cell receptor binding
GO:0042803	protein homodimerization activity
GO:0044822	poly(A) RNA binding
GO:0046982	protein heterodimerization activity
GO:0051015	actin filament binding

Biological Process

GO:0000902	cell morphogenesis
GO:0001701	in utero embryonic development
GO:0006884	cell volume homeostasis
GO:0006915	apoptotic process
GO:0006921	cellular component disassembly involved in execution phase of apoptosis
GO:0006987	activation of signaling protein activity involved in unfolded protein response
GO:0020027	hemoglobin metabolic process
GO:0030036	actin cytoskeleton organization
GO:0030218	erythrocyte differentiation
GO:0030837	negative regulation of actin filament polymerization
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0032092	positive regulation of protein binding
GO:0035264	multicellular organism growth
GO:0044267	cellular protein metabolic process
GO:0045766	positive regulation of angiogenesis
GO:0045807	positive regulation of endocytosis
GO:0048873	homeostasis of number of cells within a tissue
GO:0051016	barbed-end actin filament capping
GO:0051017	actin filament bundle assembly
GO:0071300	cellular response to retinoic acid

Cellular Component

GO:0005634	nucleus
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0008290	F-actin capping protein complex
GO:0014069	postsynaptic density
GO:0016020	membrane
GO:0030425	dendrite
GO:0043197	dendritic spine
GO:0045111	intermediate filament cytoskeleton
GO:0045202	synapse
GO:0048471	perinuclear region of cytoplasm