Bos taurus Gene: TTR
Summary
InnateDB Gene IDBG-643739.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TTR
Gene Name Transthyretin
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000010991
Encoded Proteins
Transthyretin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000118271:
This gene encodes transthyretin, one of the three prealbumins including alpha-1-antitrypsin, transthyretin and orosomucoid. Transthyretin is a carrier protein; it transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported; most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart, and a small portion of the gene mutations is non-amyloidogenic. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc. [provided by RefSeq, Jan 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 24:25854675-25863535
Strand Reverse strand
Band
Transcripts
ENSBTAT00000014585 ENSBTAP00000014585
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 46 interaction(s) predicted by orthology.
Predicted by orthology
Total 46 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005179 hormone activity
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0006810 transport
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Non-integrin membrane-ECM interactions pathway
Amyloids pathway
Extracellular matrix organization pathway
Retinoid metabolism and transport pathway
The canonical retinoid cycle in rods (twilight vision) pathway
Visual phototransduction pathway
Signal Transduction pathway
Diseases associated with visual transduction pathway
Retinoid cycle disease events pathway
Disease pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Extracellular matrix organization pathway
Retinoid metabolism and transport pathway
The canonical retinoid cycle in rods (twilight vision) pathway
Signal Transduction pathway
Amyloids pathway
Diseases associated with visual transduction pathway
Non-integrin membrane-ECM interactions pathway
Visual phototransduction pathway
Retinoid cycle disease events pathway
Disease pathway
Disease pathway
Retinoid metabolism and transport pathway
Amyloids pathway
Extracellular matrix organization pathway
The canonical retinoid cycle in rods (twilight vision) pathway
Non-integrin membrane-ECM interactions pathway
Visual phototransduction pathway
Retinoid cycle disease events pathway
Signal Transduction pathway
Diseases associated with visual transduction pathway
KEGG
INOH
PID BIOCARTA
PID NCI
FOXA2 and FOXA3 transcription factor networks
Cross-References
SwissProt O46375
TrEMBL
UniProt Splice Variant
Entrez Gene 280948
UniGene Bt.207
RefSeq NM_173967
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AB009591 BC103035
GenPept AAI03036 BAA23983
RNA Seq Atlas 280948
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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