Mus musculus Gene: Ttr
Summary
InnateDB Gene IDBG-130236.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ttr
Gene Name transthyretin
Synonyms AA408768; AI787086; D17860; prealbumin;
Species Mus musculus
Ensembl Gene ENSMUSG00000061808
Encoded Proteins
transthyretin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a carrier protein responsible for the transport of thyroid hormones and retinol. The protein consists of a tetramer of identical subunits. Due to increased stability of the tetramer form of this encoded protein in mouse, compared to the human protein, this gene product has a reduced tendency to form amyloid fibrils. In humans, this protein binds beta-amyloid preventing its aggregation and providing a neuroprotective role in Alzheimer's disease. [provided by RefSeq, Mar 2010]
This gene encodes a carrier protein responsible for the transport of thyroid hormones and retinol. The protein consists of a tetramer of identical subunits. Due to increased stability of the tetramer form of this encoded protein in mouse, compared to the human protein, this gene product has a reduced tendency to form amyloid fibrils. In humans, this protein binds beta-amyloid preventing its aggregation and providing a neuroprotective role in Alzheimer\'s disease. [provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:20665250-20674324
Strand Forward strand
Band A2
Transcripts
ENSMUST00000075312 ENSMUSP00000074783
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 45 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 4 [view]
Protein-DNA 6 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 45 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005179 hormone activity
GO:0005515 protein binding
GO:0042562 hormone binding
GO:0042802 identical protein binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006810 transport
GO:0042572 retinol metabolic process
Cellular Component
GO:0005615 extracellular space
GO:0043234 protein complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Disease pathway
Retinoid metabolism and transport pathway
Amyloids pathway
Extracellular matrix organization pathway
The canonical retinoid cycle in rods (twilight vision) pathway
Non-integrin membrane-ECM interactions pathway
Visual phototransduction pathway
Retinoid cycle disease events pathway
Signal Transduction pathway
Diseases associated with visual transduction pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Extracellular matrix organization pathway
Retinoid metabolism and transport pathway
The canonical retinoid cycle in rods (twilight vision) pathway
Signal Transduction pathway
Amyloids pathway
Diseases associated with visual transduction pathway
Non-integrin membrane-ECM interactions pathway
Visual phototransduction pathway
Retinoid cycle disease events pathway
Disease pathway
Non-integrin membrane-ECM interactions pathway
Amyloids pathway
Extracellular matrix organization pathway
Retinoid metabolism and transport pathway
The canonical retinoid cycle in rods (twilight vision) pathway
Visual phototransduction pathway
Signal Transduction pathway
Diseases associated with visual transduction pathway
Retinoid cycle disease events pathway
Disease pathway
KEGG
INOH
PID BIOCARTA
PID NCI
FOXA2 and FOXA3 transcription factor networks
Cross-References
SwissProt P07309
TrEMBL Q5M9K1
UniProt Splice Variant
Entrez Gene 22139
UniGene Mm.470364
RefSeq NM_013697
OMIM
CCDS CCDS29085
HPRD
IMGT
MGI ID MGI:98865
MGI Symbol Ttr
EMBL AK018701 AK050155 AK075588 BC024702 BC086926 CH466557 D00073 D89076 X03351
GenPept AAH24702 AAH86926 BAA00050 BAA13757 BAB31352 BAC34098 BAC35839 CAA27057 EDK96952
RNA Seq Atlas 22139