Version 5.4
Bos taurus Gene: BT.55802
Summary
InnateDB Gene IDBG-643918.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.55802
Gene Name bcl2 antagonist of cell death
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000012511
Encoded Proteins
IDBP-696515
bcl2 antagonist of cell death
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000002330:
The protein encoded by this gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 29:43190201-43201983
Strand Reverse strand
Band
Transcripts
ENSBTAT00000016610 ENSBTAP00000016610
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 43 interaction(s) predicted by orthology.
Predicted by orthology
Total 43 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005543 phospholipid binding
GO:0008289 lipid binding
GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0001836 release of cytochrome c from mitochondria
GO:0006007 glucose catabolic process
GO:0006915 apoptotic process
GO:0008283 cell proliferation
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010918 positive regulation of mitochondrial membrane potential
GO:0019050 suppression by virus of host apoptotic process
GO:0019221 cytokine-mediated signaling pathway
GO:0032024 positive regulation of insulin secretion
GO:0033133 positive regulation of glucokinase activity
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0042593 glucose homeostasis
GO:0042981 regulation of apoptotic process
GO:0043065 positive regulation of apoptotic process
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0044342 type B pancreatic cell proliferation
GO:0045579 positive regulation of B cell differentiation
GO:0045582 positive regulation of T cell differentiation
GO:0045862 positive regulation of proteolysis
GO:0046031 ADP metabolic process
GO:0046034 ATP metabolic process
GO:0046902 regulation of mitochondrial membrane permeability
GO:0046931 pore complex assembly
GO:0050679 positive regulation of epithelial cell proliferation
GO:0060139 positive regulation of apoptotic process by virus
GO:0060154 cellular process regulating host cell cycle in response to virus
GO:0071260 cellular response to mechanical stimulus
GO:0071316 cellular response to nicotine
GO:0071396 cellular response to lipid
GO:0071456 cellular response to hypoxia
GO:0090200 positive regulation of release of cytochrome c from mitochondria
GO:0097190 apoptotic signaling pathway
GO:0097191 extrinsic apoptotic signaling pathway
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:0097193 intrinsic apoptotic signaling pathway
GO:0097202 activation of cysteine-type endopeptidase activity
GO:2000078 positive regulation of type B pancreatic cell development
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005829 cytosol
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000002330
View Gene Order
ENSMUSG00000024959
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_1
Alpha6Beta4Integrin pathway
NetPath_4
EGFR1 pathway
NetPath_6
KitReceptor pathway
NetPath_14
IL2 pathway
NetPath_15
IL3 pathway
NetPath_16
IL4 pathway
NetPath_18
IL6 pathway
NetPath_19
IL-7 pathway
NetPath_21
RANKL pathway
NetPath_22
Leptin pathway
NetPath_26
TWEAK pathway
REACTOME
REACT_12564
AKT phosphorylates targets in the cytosol pathway
REACT_75829
PIP3 activates AKT signaling pathway
REACT_147814
DAP12 signaling pathway
REACT_147694
DAP12 interactions pathway
REACT_12464
PI3K/AKT activation pathway
REACT_13638
NRAGE signals death through JNK pathway
REACT_12578
GAB1 signalosome pathway
REACT_9417
Signaling by EGFR pathway
REACT_115961
PI3K events in ERBB4 signaling pathway
REACT_115596
Signaling by ERBB4 pathway
REACT_116008
PI3K events in ERBB2 signaling pathway
REACT_115755
Signaling by ERBB2 pathway
REACT_21270
PI-3K cascade pathway
REACT_9470
Signaling by FGFR pathway
REACT_111040
Signaling by SCF-KIT pathway
REACT_17025
Downstream signal transduction pathway
REACT_16888
Signaling by PDGF pathway
REACT_549
Activation of BAD and translocation to mitochondria pathway
REACT_330
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members pathway
REACT_147727
Constitutive PI3K/AKT Signaling in Cancer pathway
REACT_120736
Signaling by FGFR in disease pathway
REACT_11061
Signalling by NGF pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_21272
Downstream signaling of activated FGFR pathway
REACT_163769
Role of LAT2/NTAL/LAB on calcium mobilization pathway
REACT_6802
Innate Immune System pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_13776
p75 NTR receptor-mediated signalling pathway
REACT_578
Apoptosis pathway
REACT_111102
Signal Transduction pathway
REACT_75774
Adaptive Immune System pathway
REACT_697
Activation of BH3-only proteins pathway
REACT_6900
Immune System pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_13720
Cell death signalling via NRAGE, NRIF and NADE pathway
REACT_147723
PI3K/AKT Signaling in Cancer pathway
REACT_964
Intrinsic Pathway for Apoptosis pathway
REACT_118773
Signaling by the B Cell Receptor (BCR) pathway
REACT_118638
Downstream signaling events of B Cell Receptor (BCR) pathway
REACT_116125
Disease pathway
REACT_239142
Innate Immune System pathway
REACT_258521
Apoptosis pathway
REACT_188199
Signaling by the B Cell Receptor (BCR) pathway
REACT_188191
Signaling by ERBB2 pathway
REACT_205300
PI3K/AKT activation pathway
REACT_189085
Disease pathway
REACT_223399
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members pathway
REACT_188177
Signaling by FGFR in disease pathway
REACT_188579
Signaling by ERBB4 pathway
REACT_188578
Signaling by SCF-KIT pathway
REACT_209641
NRAGE signals death through JNK pathway
REACT_226341
PIP3 activates AKT signaling pathway
REACT_230745
Immune System pathway
REACT_230639
Downstream signal transduction pathway
REACT_231729
Downstream signaling of activated FGFR pathway
REACT_196588
Constitutive PI3K/AKT Signaling in Cancer pathway
REACT_203296
PI3K events in ERBB4 signaling pathway
REACT_223993
PI-3K cascade pathway
REACT_221775
Activation of BAD and translocation to mitochondria pathway
REACT_204413
Cell death signalling via NRAGE, NRIF and NADE pathway
REACT_242976
Signaling by EGFR pathway
REACT_213364
Role of LAT2/NTAL/LAB on calcium mobilization pathway
REACT_188204
Fc epsilon receptor (FCERI) signaling pathway
REACT_226735
PI3K/AKT Signaling in Cancer pathway
REACT_248921
Signalling by NGF pathway
REACT_212161
Activation of BH3-only proteins pathway
REACT_229531
Adaptive Immune System pathway
REACT_263353
Signaling by PDGF pathway
REACT_206286
GAB1 signalosome pathway
REACT_220918
AKT phosphorylates targets in the cytosol pathway
REACT_237883
NGF signalling via TRKA from the plasma membrane pathway
REACT_215348
PI3K events in ERBB2 signaling pathway
REACT_188257
Signal Transduction pathway
REACT_210847
p75 NTR receptor-mediated signalling pathway
REACT_242456
Signaling by FGFR pathway
REACT_188180
Signaling by EGFR in Cancer pathway
REACT_209507
Downstream signaling events of B Cell Receptor (BCR) pathway
REACT_188188
DAP12 interactions pathway
REACT_188185
DAP12 signaling pathway
REACT_204001
Intrinsic Pathway for Apoptosis pathway
KEGG
hsa05221
Acute myeloid leukemia pathway
hsa04370
VEGF signaling pathway pathway
hsa05210
Colorectal cancer pathway
hsa05223
Non-small cell lung cancer pathway
hsa04012
ErbB signaling pathway pathway
hsa04210
Apoptosis pathway
hsa05218
Melanoma pathway
hsa05213
Endometrial cancer pathway
hsa05010
Alzheimer's disease pathway
hsa04910
Insulin signaling pathway pathway
hsa05215
Prostate cancer pathway
hsa04510
Focal adhesion pathway
hsa05220
Chronic myeloid leukemia pathway
hsa05212
Pancreatic cancer pathway
hsa05014
Amyotrophic lateral sclerosis (ALS) pathway
hsa04722
Neurotrophin signaling pathway pathway
hsa05200
Pathways in cancer pathway
hsa05145
Toxoplasmosis pathway
hsa05160
Hepatitis C pathway
mmu05213
Endometrial cancer pathway
mmu04012
ErbB signaling pathway pathway
mmu04370
VEGF signaling pathway pathway
mmu04910
Insulin signaling pathway pathway
mmu05221
Acute myeloid leukemia pathway
mmu05010
Alzheimer's disease pathway
mmu05210
Colorectal cancer pathway
mmu05218
Melanoma pathway
mmu04210
Apoptosis pathway
mmu05215
Prostate cancer pathway
mmu05220
Chronic myeloid leukemia pathway
mmu05223
Non-small cell lung cancer pathway
mmu04510
Focal adhesion pathway
mmu05212
Pancreatic cancer pathway
mmu05014
Amyotrophic lateral sclerosis (ALS) pathway
mmu04722
Neurotrophin signaling pathway pathway
mmu05200
Pathways in cancer pathway
mmu05145
Toxoplasmosis pathway
mmu05160
Hepatitis C pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
EPO signaling pathway pathway
INOH website
Insulin receptor signaling pathway
INOH website
VEGF signaling pathway pathway
INOH website
IL-7 signaling pathway
INOH website
EPO signaling pathway pathway
INOH website
Insulin receptor signaling pathway
INOH website
VEGF signaling pathway pathway
PID NCI
pi3kplctrkpathway
Trk receptor signaling mediated by PI3K and PLC-gamma
nephrin_neph1_pathway
Nephrin/Neph1 signaling in the kidney podocyte
ceramide_pathway
Ceramide signaling pathway
alphasynuclein_pathway
Alpha-synuclein signaling
met_pathway
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
pi3kciaktpathway
Class I PI3K signaling events mediated by Akt
cxcr4_pathway
CXCR4-mediated signaling events
erbb1_downstream_pathway
ErbB1 downstream signaling
igf1_pathway
IGF1 pathway
p75ntrpathway
p75(NTR)-mediated signaling
kitpathway
Signaling events mediated by Stem cell factor receptor (c-Kit)
erbb2erbb3pathway
ErbB2/ErbB3 signaling events
nfat_3pathway
Role of Calcineurin-dependent NFAT signaling in lymphocytes
Cross-References
SwissProt
TrEMBL F1MUT9
UniProt Splice Variant
Entrez Gene 615013
UniGene Bt.55802
RefSeq NM_001035459 XM_005227184 XM_005227185 XM_005227186 XM_005227187
HUGO HGNC:936
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02063532
GenPept
RNA Seq Atlas 615013

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca