Homo sapiens Gene: BAD
Summary
InnateDB Gene IDBG-53423.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BAD
Gene Name BCL2-associated agonist of cell death
Synonyms BBC2; BCL2L8;
Species Homo sapiens
Ensembl Gene ENSG00000002330
Encoded Proteins
BCL2-associated agonist of cell death
BCL2-associated agonist of cell death
BCL2-associated agonist of cell death
BCL2-associated agonist of cell death
BCL2-associated agonist of cell death
BCL2-associated agonist of cell death
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:64269830-64284704
Strand Reverse strand
Band q13.1
Transcripts
ENST00000309032 ENSP00000309103
ENST00000394532 ENSP00000378040
ENST00000394531 ENSP00000378039
ENST00000493798 ENSP00000438975
ENST00000492141 ENSP00000439202
ENST00000544785 ENSP00000440575
ENST00000544271
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 61 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 61 [view]
Protein-Protein 59 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005543 phospholipid binding
GO:0008289 lipid binding
GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0030346 protein phosphatase 2B binding
GO:0043422 protein kinase B binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0001666 response to hypoxia
GO:0001836 release of cytochrome c from mitochondria
GO:0006007 glucose catabolic process
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0008283 cell proliferation
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0009725 response to hormone
GO:0009749 response to glucose
GO:0010033 response to organic substance
GO:0010508 positive regulation of autophagy
GO:0010918 positive regulation of mitochondrial membrane potential
GO:0014070 response to organic cyclic compound
GO:0019050 suppression by virus of host apoptotic process
GO:0019221 cytokine-mediated signaling pathway
GO:0032024 positive regulation of insulin secretion
GO:0032355 response to estradiol
GO:0032570 response to progesterone
GO:0033133 positive regulation of glucokinase activity
GO:0033574 response to testosterone
GO:0034201 response to oleic acid
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0042493 response to drug
GO:0042542 response to hydrogen peroxide
GO:0042593 glucose homeostasis
GO:0042981 regulation of apoptotic process
GO:0043065 positive regulation of apoptotic process
GO:0043200 response to amino acid
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0044342 type B pancreatic cell proliferation
GO:0045087 innate immune response
GO:0045471 response to ethanol
GO:0045579 positive regulation of B cell differentiation
GO:0045582 positive regulation of T cell differentiation
GO:0045862 positive regulation of proteolysis
GO:0046031 ADP metabolic process
GO:0046034 ATP metabolic process
GO:0046902 regulation of mitochondrial membrane permeability
GO:0046931 pore complex assembly
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0050679 positive regulation of epithelial cell proliferation
GO:0051384 response to glucocorticoid
GO:0051592 response to calcium ion
GO:0060139 positive regulation of apoptotic process by virus
GO:0060154 cellular process regulating host cell cycle in response to virus
GO:0071247 cellular response to chromate
GO:0071260 cellular response to mechanical stimulus
GO:0071316 cellular response to nicotine
GO:0071396 cellular response to lipid
GO:0071456 cellular response to hypoxia
GO:0090200 positive regulation of release of cytochrome c from mitochondria
GO:0097190 apoptotic signaling pathway
GO:0097191 extrinsic apoptotic signaling pathway
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:0097193 intrinsic apoptotic signaling pathway
GO:0097202 activation of cysteine-type endopeptidase activity
GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:1901216 positive regulation of neuron death
GO:2000078 positive regulation of type B pancreatic cell development
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
Alpha6Beta4Integrin pathway
EGFR1 pathway
KitReceptor pathway
IL2 pathway
IL3 pathway
IL4 pathway
IL6 pathway
IL-7 pathway
RANKL pathway
Leptin pathway
TWEAK pathway
REACTOME
Signaling by FGFR in disease pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
PI3K/AKT activation pathway
Downstream signaling of activated FGFR pathway
PI-3K cascade pathway
PI3K events in ERBB2 signaling pathway
DAP12 signaling pathway
Signaling by EGFR pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Constitutive PI3K/AKT Signaling in Cancer pathway
Innate Immune System pathway
Signaling by ERBB4 pathway
Signaling by SCF-KIT pathway
Fc epsilon receptor (FCERI) signaling pathway
p75 NTR receptor-mediated signalling pathway
Apoptosis pathway
Signal Transduction pathway
NRAGE signals death through JNK pathway
AKT phosphorylates targets in the cytosol pathway
Adaptive Immune System pathway
Activation of BH3-only proteins pathway
Immune System pathway
Downstream signal transduction pathway
NGF signalling via TRKA from the plasma membrane pathway
Cell death signalling via NRAGE, NRIF and NADE pathway
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members pathway
PI3K/AKT Signaling in Cancer pathway
Signaling by FGFR pathway
PIP3 activates AKT signaling pathway
Signaling by PDGF pathway
Intrinsic Pathway for Apoptosis pathway
Signaling by ERBB2 pathway
Signaling by the B Cell Receptor (BCR) pathway
GAB1 signalosome pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
Disease pathway
Activation of BAD and translocation to mitochondria pathway
PI3K events in ERBB4 signaling pathway
DAP12 interactions pathway
KEGG
ErbB signaling pathway pathway
Apoptosis pathway
VEGF signaling pathway pathway
Focal adhesion pathway
Neurotrophin signaling pathway pathway
Insulin signaling pathway pathway
Alzheimer's disease pathway
Amyotrophic lateral sclerosis (ALS) pathway
Toxoplasmosis pathway
Hepatitis C pathway
Pathways in cancer pathway
Colorectal cancer pathway
Pancreatic cancer pathway
Endometrial cancer pathway
Prostate cancer pathway
Melanoma pathway
Chronic myeloid leukemia pathway
Acute myeloid leukemia pathway
Non-small cell lung cancer pathway
INOH
IL-7 signaling pathway
EPO signaling pathway pathway
Insulin receptor signaling pathway
VEGF signaling pathway pathway
PID BIOCARTA
Role of nicotinic acetylcholine receptors in the regulation of apoptosis [Biocarta view]
Il-2 receptor beta chain in t cell activation [Biocarta view]
Trefoil factors initiate mucosal healing [Biocarta view]
Apoptotic signaling in response to dna damage [Biocarta view]
Multiple antiapoptotic pathways from igf-1r signaling lead to bad phosphorylation [Biocarta view]
Ras signaling pathway [Biocarta view]
Regulation of bad phosphorylation [Biocarta view]
Ceramide signaling pathway [Biocarta view]
Phosphoinositides and their downstream targets [Biocarta view]
Akt signaling pathway [Biocarta view]
PID NCI
Trk receptor signaling mediated by PI3K and PLC-gamma
Nephrin/Neph1 signaling in the kidney podocyte
Ceramide signaling pathway
Alpha-synuclein signaling
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
Class I PI3K signaling events mediated by Akt
CXCR4-mediated signaling events
ErbB1 downstream signaling
IGF1 pathway
p75(NTR)-mediated signaling
Signaling events mediated by Stem cell factor receptor (c-Kit)
ErbB2/ErbB3 signaling events
Role of Calcineurin-dependent NFAT signaling in lymphocytes
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_004322 NM_032989
HUGO
OMIM
CCDS CCDS8065
HPRD 04409
IMGT
EMBL
GenPept
RNA Seq Atlas