Version 5.4
Homo sapiens Gene: BAD
Summary
InnateDB Gene IDBG-53423.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BAD
Gene Name BCL2-associated agonist of cell death
Synonyms BBC2; BCL2L8;
Species Homo sapiens
Ensembl Gene ENSG00000002330
Encoded Proteins
IDBP-53425
BCL2-associated agonist of cell death
IDBP-241405
BCL2-associated agonist of cell death
IDBP-241407
BCL2-associated agonist of cell death
IDBP-594103
BCL2-associated agonist of cell death
IDBP-596999
BCL2-associated agonist of cell death
IDBP-598751
BCL2-associated agonist of cell death
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:64269830-64284704
Strand Reverse strand
Band q13.1
Transcripts
ENST00000309032 ENSP00000309103
ENST00000394532 ENSP00000378040
ENST00000394531 ENSP00000378039
ENST00000493798 ENSP00000438975
ENST00000492141 ENSP00000439202
ENST00000544785 ENSP00000440575
ENST00000544271
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 61 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 61 [view]
Protein-Protein 59 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005543 phospholipid binding
GO:0008289 lipid binding
GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0030346 protein phosphatase 2B binding
GO:0043422 protein kinase B binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0001666 response to hypoxia
GO:0001836 release of cytochrome c from mitochondria
GO:0006007 glucose catabolic process
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0008283 cell proliferation
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0009725 response to hormone
GO:0009749 response to glucose
GO:0010033 response to organic substance
GO:0010508 positive regulation of autophagy
GO:0010918 positive regulation of mitochondrial membrane potential
GO:0014070 response to organic cyclic compound
GO:0019050 suppression by virus of host apoptotic process
GO:0019221 cytokine-mediated signaling pathway
GO:0032024 positive regulation of insulin secretion
GO:0032355 response to estradiol
GO:0032570 response to progesterone
GO:0033133 positive regulation of glucokinase activity
GO:0033574 response to testosterone
GO:0034201 response to oleic acid
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0042493 response to drug
GO:0042542 response to hydrogen peroxide
GO:0042593 glucose homeostasis
GO:0042981 regulation of apoptotic process
GO:0043065 positive regulation of apoptotic process
GO:0043200 response to amino acid
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0044342 type B pancreatic cell proliferation
GO:0045087 innate immune response
GO:0045471 response to ethanol
GO:0045579 positive regulation of B cell differentiation
GO:0045582 positive regulation of T cell differentiation
GO:0045862 positive regulation of proteolysis
GO:0046031 ADP metabolic process
GO:0046034 ATP metabolic process
GO:0046902 regulation of mitochondrial membrane permeability
GO:0046931 pore complex assembly
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0050679 positive regulation of epithelial cell proliferation
GO:0051384 response to glucocorticoid
GO:0051592 response to calcium ion
GO:0060139 positive regulation of apoptotic process by virus
GO:0060154 cellular process regulating host cell cycle in response to virus
GO:0071247 cellular response to chromate
GO:0071260 cellular response to mechanical stimulus
GO:0071316 cellular response to nicotine
GO:0071396 cellular response to lipid
GO:0071456 cellular response to hypoxia
GO:0090200 positive regulation of release of cytochrome c from mitochondria
GO:0097190 apoptotic signaling pathway
GO:0097191 extrinsic apoptotic signaling pathway
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:0097193 intrinsic apoptotic signaling pathway
GO:0097202 activation of cysteine-type endopeptidase activity
GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:1901216 positive regulation of neuron death
GO:2000078 positive regulation of type B pancreatic cell development
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
ENSMUSG00000024959
View Gene Order
Ortholuge
SSD Ortholog
Ortholog supports species divergence
ENSBTAG00000012511
Not yet available
Ortholuge
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
NetPath_1
Alpha6Beta4Integrin pathway
NetPath_4
EGFR1 pathway
NetPath_6
KitReceptor pathway
NetPath_14
IL2 pathway
NetPath_15
IL3 pathway
NetPath_16
IL4 pathway
NetPath_18
IL6 pathway
NetPath_19
IL-7 pathway
NetPath_21
RANKL pathway
NetPath_22
Leptin pathway
NetPath_26
TWEAK pathway
REACTOME
REACT_120736
Signaling by FGFR in disease pathway
REACT_11061
Signalling by NGF pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_12464
PI3K/AKT activation pathway
REACT_21272
Downstream signaling of activated FGFR pathway
REACT_21270
PI-3K cascade pathway
REACT_116008
PI3K events in ERBB2 signaling pathway
REACT_147814
DAP12 signaling pathway
REACT_9417
Signaling by EGFR pathway
REACT_163769
Role of LAT2/NTAL/LAB on calcium mobilization pathway
REACT_147727
Constitutive PI3K/AKT Signaling in Cancer pathway
REACT_6802
Innate Immune System pathway
REACT_115596
Signaling by ERBB4 pathway
REACT_111040
Signaling by SCF-KIT pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_13776
p75 NTR receptor-mediated signalling pathway
REACT_578
Apoptosis pathway
REACT_111102
Signal Transduction pathway
REACT_13638
NRAGE signals death through JNK pathway
REACT_12564
AKT phosphorylates targets in the cytosol pathway
REACT_75774
Adaptive Immune System pathway
REACT_697
Activation of BH3-only proteins pathway
REACT_6900
Immune System pathway
REACT_17025
Downstream signal transduction pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_13720
Cell death signalling via NRAGE, NRIF and NADE pathway
REACT_330
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members pathway
REACT_147723
PI3K/AKT Signaling in Cancer pathway
REACT_9470
Signaling by FGFR pathway
REACT_75829
PIP3 activates AKT signaling pathway
REACT_16888
Signaling by PDGF pathway
REACT_964
Intrinsic Pathway for Apoptosis pathway
REACT_115755
Signaling by ERBB2 pathway
REACT_118773
Signaling by the B Cell Receptor (BCR) pathway
REACT_12578
GAB1 signalosome pathway
REACT_118638
Downstream signaling events of B Cell Receptor (BCR) pathway
REACT_116125
Disease pathway
REACT_549
Activation of BAD and translocation to mitochondria pathway
REACT_115961
PI3K events in ERBB4 signaling pathway
REACT_147694
DAP12 interactions pathway
KEGG
hsa04012
ErbB signaling pathway pathway
hsa04210
Apoptosis pathway
hsa04370
VEGF signaling pathway pathway
hsa04510
Focal adhesion pathway
hsa04722
Neurotrophin signaling pathway pathway
hsa04910
Insulin signaling pathway pathway
hsa05010
Alzheimer's disease pathway
hsa05014
Amyotrophic lateral sclerosis (ALS) pathway
hsa05145
Toxoplasmosis pathway
hsa05160
Hepatitis C pathway
hsa05200
Pathways in cancer pathway
hsa05210
Colorectal cancer pathway
hsa05212
Pancreatic cancer pathway
hsa05213
Endometrial cancer pathway
hsa05215
Prostate cancer pathway
hsa05218
Melanoma pathway
hsa05220
Chronic myeloid leukemia pathway
hsa05221
Acute myeloid leukemia pathway
hsa05223
Non-small cell lung cancer pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
EPO signaling pathway pathway
INOH website
Insulin receptor signaling pathway
INOH website
VEGF signaling pathway pathway
PID BIOCARTA
100255
Role of nicotinic acetylcholine receptors in the regulation of apoptosis [Biocarta view]
100129
Il-2 receptor beta chain in t cell activation [Biocarta view]
100018
Trefoil factors initiate mucosal healing [Biocarta view]
100204
Apoptotic signaling in response to dna damage [Biocarta view]
100135
Multiple antiapoptotic pathways from igf-1r signaling lead to bad phosphorylation [Biocarta view]
100047
Ras signaling pathway [Biocarta view]
100233
Regulation of bad phosphorylation [Biocarta view]
100206
Ceramide signaling pathway [Biocarta view]
100059
Phosphoinositides and their downstream targets [Biocarta view]
100245
Akt signaling pathway [Biocarta view]
PID NCI
pi3kplctrkpathway
Trk receptor signaling mediated by PI3K and PLC-gamma
nephrin_neph1_pathway
Nephrin/Neph1 signaling in the kidney podocyte
ceramide_pathway
Ceramide signaling pathway
alphasynuclein_pathway
Alpha-synuclein signaling
met_pathway
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
pi3kciaktpathway
Class I PI3K signaling events mediated by Akt
cxcr4_pathway
CXCR4-mediated signaling events
erbb1_downstream_pathway
ErbB1 downstream signaling
igf1_pathway
IGF1 pathway
p75ntrpathway
p75(NTR)-mediated signaling
kitpathway
Signaling events mediated by Stem cell factor receptor (c-Kit)
erbb2erbb3pathway
ErbB2/ErbB3 signaling events
nfat_3pathway
Role of Calcineurin-dependent NFAT signaling in lymphocytes
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_004322 NM_032989
HUGO
OMIM
CCDS CCDS8065
HPRD 04409
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca