Version 5.4
Bos taurus Gene: RALBP1
Summary
InnateDB Gene IDBG-644326.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RALBP1
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000021250
Encoded Proteins
IDBP-696975
ralA binding protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000017797:
RALBP1 plays a role in receptor-mediated endocytosis and is a downstream effector of the small GTP-binding protein RAL (see RALA; MIM 179550). Small G proteins, such as RAL, have GDP-bound inactive and GTP-bound active forms, which shift from the inactive to the active state through the action of RALGDS (MIM 601619), which in turn is activated by RAS (see HRAS; MIM 190020) (summary by Feig, 2003 [PubMed 12888294]).[supplied by OMIM, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 24:42061941-42079438
Strand Forward strand
Band
Transcripts
ENSBTAT00000061174 ENSBTAP00000053388
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.
Predicted by orthology
Total 26 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005096 GTPase activator activity
GO:0005515 protein binding
GO:0016887 ATPase activity
GO:0017160 Ral GTPase binding
GO:0030675 Rac GTPase activator activity
GO:0043492 ATPase activity, coupled to movement of substances
GO:0048365 Rac GTPase binding
Biological Process
GO:0006200 ATP catabolic process
GO:0006810 transport
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0032855 positive regulation of Rac GTPase activity
GO:0043087 regulation of GTPase activity
GO:0043089 positive regulation of Cdc42 GTPase activity
Cellular Component
GO:0005622 intracellular
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000017797
View Gene Order
ENSMUSG00000024096
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
REACT_11051
Rho GTPase cycle pathway
REACT_11044
Signaling by Rho GTPases pathway
REACT_111102
Signal Transduction pathway
REACT_206918
Signaling by Rho GTPases pathway
REACT_210090
Rho GTPase cycle pathway
REACT_188257
Signal Transduction pathway
KEGG
hsa05212
Pancreatic cancer pathway
hsa05200
Pathways in cancer pathway
mmu05212
Pancreatic cancer pathway
mmu05200
Pathways in cancer pathway
INOH
PID NCI
rac1_reg_pathway
Regulation of RAC1 activity
cdc42_reg_pathway
Regulation of CDC42 activity
Cross-References
SwissProt
TrEMBL F1MPV3
UniProt Splice Variant
Entrez Gene 523324
UniGene Bt.60596
RefSeq XM_002697745 XM_005196756 XM_005196757 XM_005224302 XM_005224303 XM_866188
HUGO HGNC:9841
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02056817
GenPept
RNA Seq Atlas 523324

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca