InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ralbp1

Summary

InnateDB Gene

IDBG-195143.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ralbp1

Gene Name

ralA binding protein 1

Synonyms

Rip1; RLIP76

Species

Mus musculus

Ensembl Gene

ENSMUSG00000024096

Encoded Proteins

IDBP-195145

ralA binding protein 1

IDBP-627174

ralA binding protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000017797:
RALBP1 plays a role in receptor-mediated endocytosis and is a downstream effector of the small GTP-binding protein RAL (see RALA; MIM 179550). Small G proteins, such as RAL, have GDP-bound inactive and GTP-bound active forms, which shift from the inactive to the active state through the action of RALGDS (MIM 601619), which in turn is activated by RAS (see HRAS; MIM 190020) (summary by Feig, 2003 [PubMed 12888294]).[supplied by OMIM, Nov 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:65848433-65885755

Strand

Reverse strand

Band

E1.1

Transcripts

ENSMUST00000024905	ENSMUSP00000024905
ENSMUST00000166543	ENSMUSP00000129448

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	26 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005096	GTPase activator activity
GO:0005515	protein binding
GO:0016887	ATPase activity
GO:0017160	Ral GTPase binding
GO:0030675	Rac GTPase activator activity
GO:0043492	ATPase activity, coupled to movement of substances
GO:0048365	Rac GTPase binding

Biological Process

GO:0006200	ATP catabolic process
GO:0006810	transport
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0032855	positive regulation of Rac GTPase activity
GO:0043087	regulation of GTPase activity
GO:0043089	positive regulation of Cdc42 GTPase activity