Version 5.4
Bos taurus Gene: SOX17
Summary
InnateDB Gene IDBG-644418.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SOX17
Gene Name transcription factor SOX-17
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000005748
Encoded Proteins
IDBP-697053
SRY (sex determining region Y)-box 17
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000164736:
This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:23884842-23886642
Strand Forward strand
Band
Transcripts
ENSBTAT00000007553 ENSBTAP00000007553
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
GO:0008013 beta-catenin binding
GO:0008134 transcription factor binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001525 angiogenesis
GO:0001570 vasculogenesis
GO:0001706 endoderm formation
GO:0001828 inner cell mass cellular morphogenesis
GO:0001947 heart looping
GO:0003142 cardiogenic plate morphogenesis
GO:0003143 embryonic heart tube morphogenesis
GO:0003151 outflow tract morphogenesis
GO:0003308 negative regulation of Wnt receptor signaling pathway involved in heart development
GO:0006355 regulation of transcription, DNA-templated
GO:0007283 spermatogenesis
GO:0007369 gastrulation
GO:0007492 endoderm development
GO:0007493 endodermal cell fate determination
GO:0010628 positive regulation of gene expression
GO:0021903 rostrocaudal neural tube patterning
GO:0023019 signal transduction involved in regulation of gene expression
GO:0030178 negative regulation of Wnt signaling pathway
GO:0030308 negative regulation of cell growth
GO:0031648 protein destabilization
GO:0035050 embryonic heart tube development
GO:0042074 cell migration involved in gastrulation
GO:0042661 regulation of mesodermal cell fate specification
GO:0042662 negative regulation of mesodermal cell fate specification
GO:0042789 mRNA transcription from RNA polymerase II promoter
GO:0045595 regulation of cell differentiation
GO:0045597 positive regulation of cell differentiation
GO:0045732 positive regulation of protein catabolic process
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0045995 regulation of embryonic development
GO:0048568 embryonic organ development
GO:0048617 embryonic foregut morphogenesis
GO:0048643 positive regulation of skeletal muscle tissue development
GO:0048863 stem cell differentiation
GO:0048866 stem cell fate specification
GO:0050821 protein stabilization
GO:0060070 canonical Wnt signaling pathway
GO:0060214 endocardium formation
GO:0060807 regulation of transcription from RNA polymerase II promoter involved in definitive endodermal cell fate specification
GO:0060913 cardiac cell fate determination
GO:0060956 endocardial cell differentiation
GO:0061009 common bile duct development
GO:0061010 gall bladder development
GO:0061031 endodermal digestive tract morphogenesis
GO:0072001 renal system development
GO:0072091 regulation of stem cell proliferation
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:2000035 regulation of stem cell division
GO:2000043 regulation of cardiac cell fate specification
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0044798 nuclear transcription factor complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000164736
View Gene Order
ENSMUSG00000025902
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04310
Wnt signaling pathway pathway
mmu04310
Wnt signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F1N1F9
UniProt Splice Variant
Entrez Gene 534010
UniGene Bt.112292
RefSeq NM_001206251
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02038302
GenPept
RNA Seq Atlas 534010

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca