Version 5.4
Bos taurus Protein: SOX17
Summary
InnateDB Protein IDBP-697053.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SOX17
Protein Name SRY (sex determining region Y)-box 17
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000007553
InnateDB Gene IDBG-644418 (SOX17)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
GO:0008013 beta-catenin binding
GO:0008134 transcription factor binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001525 angiogenesis
GO:0001570 vasculogenesis
GO:0001706 endoderm formation
GO:0001828 inner cell mass cellular morphogenesis
GO:0001947 heart looping
GO:0003142 cardiogenic plate morphogenesis
GO:0003143 embryonic heart tube morphogenesis
GO:0003151 outflow tract morphogenesis
GO:0003308 negative regulation of Wnt receptor signaling pathway involved in heart development
GO:0006355 regulation of transcription, DNA-templated
GO:0007283 spermatogenesis
GO:0007369 gastrulation
GO:0007492 endoderm development
GO:0007493 endodermal cell fate determination
GO:0010628 positive regulation of gene expression
GO:0021903 rostrocaudal neural tube patterning
GO:0023019 signal transduction involved in regulation of gene expression
GO:0030178 negative regulation of Wnt signaling pathway
GO:0030308 negative regulation of cell growth
GO:0031648 protein destabilization
GO:0035050 embryonic heart tube development
GO:0042074 cell migration involved in gastrulation
GO:0042661 regulation of mesodermal cell fate specification
GO:0042662 negative regulation of mesodermal cell fate specification
GO:0042789 mRNA transcription from RNA polymerase II promoter
GO:0045595 regulation of cell differentiation
GO:0045597 positive regulation of cell differentiation
GO:0045732 positive regulation of protein catabolic process
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0045995 regulation of embryonic development
GO:0048568 embryonic organ development
GO:0048617 embryonic foregut morphogenesis
GO:0048643 positive regulation of skeletal muscle tissue development
GO:0048863 stem cell differentiation
GO:0048866 stem cell fate specification
GO:0050821 protein stabilization
GO:0060070 canonical Wnt signaling pathway
GO:0060214 endocardium formation
GO:0060807 regulation of transcription from RNA polymerase II promoter involved in definitive endodermal cell fate specification
GO:0060913 cardiac cell fate determination
GO:0060956 endocardial cell differentiation
GO:0061009 common bile duct development
GO:0061010 gall bladder development
GO:0061031 endodermal digestive tract morphogenesis
GO:0072001 renal system development
GO:0072091 regulation of stem cell proliferation
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:2000035 regulation of stem cell division
GO:2000043 regulation of cardiac cell fate specification
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0044798 nuclear transcription factor complex
Protein Structure and Domains
PDB ID
InterPro IPR009071 High mobility group box domain
IPR021934 Sox C-terminal transactivation domain
PFAM PF00505
PF09011
PF12067
PRINTS
PIRSF
SMART SM00398
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL F1N1F9
UniProt Splice Variant
Entrez Gene 534010
UniGene Bt.112292
RefSeq NP_001193180
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02038302
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca