Bos taurus Gene: LMAN1
Summary
InnateDB Gene IDBG-644907.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LMAN1
Gene Name protein ERGIC-53 precursor
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000006833
Encoded Proteins
protein ERGIC-53
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000074695:
The protein encoded by this gene is a type I integral membrane protein localized in the intermediate region between the endoplasmic reticulum and the Golgi, presumably recycling between the two compartments. The protein is a mannose-specific lectin and is a member of a novel family of plant lectin homologs in the secretory pathway of animal cells. Mutations in the gene are associated with a coagulation defect. Using positional cloning, the gene was identified as the disease gene leading to combined factor V-factor VIII deficiency, a rare, autosomal recessive disorder in which both coagulation factors V and VIII are diminished. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 24:58797010-58815897
Strand Reverse strand
Band
Transcripts
ENSBTAT00000008979 ENSBTAP00000008979
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.
Predicted by orthology
Total 28 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007029 endoplasmic reticulum organization
GO:0007030 Golgi organization
GO:0010638 positive regulation of organelle organization
Cellular Component
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0030017 sarcomere
GO:0030134 ER to Golgi transport vesicle
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Post-translational protein modification pathway
Asparagine N-linked glycosylation pathway
Metabolism of proteins pathway
Transport to the Golgi and subsequent modification pathway
Transport to the Golgi and subsequent modification pathway
Metabolism of proteins pathway
Post-translational protein modification pathway
Asparagine N-linked glycosylation pathway
KEGG
Protein processing in endoplasmic reticulum pathway
Protein processing in endoplasmic reticulum pathway
INOH
PID BIOCARTA
PID NCI
Signaling events mediated by TCPTP
Cross-References
SwissProt
TrEMBL F1ME46 Q8MJ82
UniProt Splice Variant
Entrez Gene 511649
UniGene
RefSeq
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AF515847 DAAA02057181 DAAA02057182
GenPept AAN03861
RNA Seq Atlas 511649
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

(Move your mouse over the image to view a more detailed version)