Mus musculus Gene: Lman1
Summary
InnateDB Gene IDBG-154877.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lman1
Gene Name lectin, mannose-binding, 1
Synonyms 2610020P13Rik; AI326273; AU043785; C730041J05; ERGIC53; F5F8D; gp58; MCFD1; MR60; P58;
Species Mus musculus
Ensembl Gene ENSMUSG00000041891
Encoded Proteins
lectin, mannose-binding, 1
lectin, mannose-binding, 1
lectin, mannose-binding, 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000074695:
The protein encoded by this gene is a type I integral membrane protein localized in the intermediate region between the endoplasmic reticulum and the Golgi, presumably recycling between the two compartments. The protein is a mannose-specific lectin and is a member of a novel family of plant lectin homologs in the secretory pathway of animal cells. Mutations in the gene are associated with a coagulation defect. Using positional cloning, the gene was identified as the disease gene leading to combined factor V-factor VIII deficiency, a rare, autosomal recessive disorder in which both coagulation factors V and VIII are diminished. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:65980754-66022580
Strand Reverse strand
Band E1
Transcripts
ENSMUST00000048260 ENSMUSP00000040140
ENSMUST00000120461 ENSMUSP00000113326
ENSMUST00000155895
ENSMUST00000144793
ENSMUST00000143990 ENSMUSP00000116433
ENSMUST00000150133
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 30 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006888 ER to Golgi vesicle-mediated transport
GO:0007029 endoplasmic reticulum organization
GO:0007030 Golgi organization
GO:0010638 positive regulation of organelle organization
GO:0015031 protein transport
Cellular Component
GO:0000139 Golgi membrane
GO:0005789 endoplasmic reticulum membrane
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030017 sarcomere
GO:0030134 ER to Golgi transport vesicle
GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Transport to the Golgi and subsequent modification pathway
Metabolism of proteins pathway
Post-translational protein modification pathway
Asparagine N-linked glycosylation pathway
KEGG
Protein processing in endoplasmic reticulum pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Post-translational protein modification pathway
Asparagine N-linked glycosylation pathway
Metabolism of proteins pathway
Transport to the Golgi and subsequent modification pathway
KEGG
Protein processing in endoplasmic reticulum pathway
INOH
PID BIOCARTA
PID NCI
Signaling events mediated by TCPTP
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.290857 Mm.399676 Mm.408877
RefSeq NM_001172062 NM_027400
OMIM
CCDS CCDS29313
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas