InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Lman1

Summary

InnateDB Gene

IDBG-154877.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lman1

Gene Name

lectin, mannose-binding, 1

Synonyms

2610020P13Rik; AI326273; AU043785; C730041J05; ERGIC53; F5F8D; gp58; MCFD1; MR60; P58

Species

Mus musculus

Ensembl Gene

ENSMUSG00000041891

Encoded Proteins

IDBP-154879

lectin, mannose-binding, 1

IDBP-401302

lectin, mannose-binding, 1

IDBP-540106

lectin, mannose-binding, 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000074695:
The protein encoded by this gene is a type I integral membrane protein localized in the intermediate region between the endoplasmic reticulum and the Golgi, presumably recycling between the two compartments. The protein is a mannose-specific lectin and is a member of a novel family of plant lectin homologs in the secretory pathway of animal cells. Mutations in the gene are associated with a coagulation defect. Using positional cloning, the gene was identified as the disease gene leading to combined factor V-factor VIII deficiency, a rare, autosomal recessive disorder in which both coagulation factors V and VIII are diminished. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:65980754-66022580

Strand

Reverse strand

Band

Transcripts

ENSMUST00000048260	ENSMUSP00000040140
ENSMUST00000120461	ENSMUSP00000113326
ENSMUST00000155895
ENSMUST00000144793
ENSMUST00000143990	ENSMUSP00000116433
ENSMUST00000150133

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	30 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0006888	ER to Golgi vesicle-mediated transport
GO:0007029	endoplasmic reticulum organization
GO:0007030	Golgi organization
GO:0010638	positive regulation of organelle organization
GO:0015031	protein transport

Cellular Component

GO:0000139	Golgi membrane
GO:0005789	endoplasmic reticulum membrane
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
GO:0005794	Golgi apparatus
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030017	sarcomere
GO:0030134	ER to Golgi transport vesicle
GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane
GO:0070062	extracellular vesicular exosome