Homo sapiens Gene: ICAM2
Summary
InnateDB Gene IDBG-64502.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ICAM2
Gene Name intercellular adhesion molecule 2
Synonyms CD102;
Species Homo sapiens
Ensembl Gene ENSG00000108622
Encoded Proteins
intercellular adhesion molecule 2
intercellular adhesion molecule 2
intercellular adhesion molecule 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:64002594-64020634
Strand Reverse strand
Band q23.3
Transcripts
ENST00000412356 ENSP00000415283
ENST00000418105 ENSP00000388666
ENST00000449662 ENSP00000392634
ENST00000584084 ENSP00000463862
ENST00000583684 ENSP00000462617
ENST00000581417
ENST00000579687 ENSP00000462579
ENST00000583366 ENSP00000463945
ENST00000580011
ENST00000578313 ENSP00000464331
ENST00000584403
ENST00000578379 ENSP00000463199
ENST00000580389
ENST00000583186
ENST00000578892 ENSP00000464372
ENST00000579788 ENSP00000464665
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005178 integrin binding
GO:0005515 protein binding
Biological Process
GO:0016337 single organismal cell-cell adhesion
GO:0030198 extracellular matrix organization
GO:0050776 regulation of immune response
Cellular Component
GO:0001931 uropod
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
GO:0071944 cell periphery
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
TSLP pathway
REACTOME
Extracellular matrix organization pathway
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
Adaptive Immune System pathway
Integrin cell surface interactions pathway
Immune System pathway
KEGG
Cell adhesion molecules (CAMs) pathway
Natural killer cell mediated cytotoxicity pathway
INOH
PID BIOCARTA
PID NCI
Beta2 integrin cell surface interactions
Cross-References
SwissProt P13598
TrEMBL J3QKR4 J3QQR8 J3QQX6 J3QRQ1 Q59ED3 Q6FHE2 Q9NZC6
UniProt Splice Variant
Entrez Gene 3384
UniGene
RefSeq NM_001099788 NM_000873 NM_001099786 NM_001099787 NM_001099789
HUGO HGNC:5345
OMIM 146630
CCDS CCDS11657
HPRD 00888
IMGT
EMBL AB209878 AC005803 AF212826 AF340052 AF340053 AK223219 BC003097 CH471109 CR541812 CR541834 M32331 M32332 M32333 M32334 X15606
GenPept AAA36035 AAF34580 AAH03097 AAQ14909 AAQ14910 BAD93115 BAD96939 CAA33630 CAG46611 CAG46633 EAW94216
RNA Seq Atlas 3384