InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ICAM2

Summary

InnateDB Gene

IDBG-64502.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ICAM2

Gene Name

intercellular adhesion molecule 2

Synonyms

CD102

Species

Homo sapiens

Ensembl Gene

ENSG00000108622

Encoded Proteins

IDBP-383425

intercellular adhesion molecule 2

IDBP-383427

intercellular adhesion molecule 2

IDBP-383430

intercellular adhesion molecule 2

IDBP-759949

IDBP-759237

IDBP-762349

IDBP-759754

IDBP-764835

IDBP-762020

IDBP-764368

IDBP-764560

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:64002594-64020634

Strand

Reverse strand

Band

q23.3

Transcripts

ENST00000412356	ENSP00000415283
ENST00000418105	ENSP00000388666
ENST00000449662	ENSP00000392634
ENST00000584084	ENSP00000463862
ENST00000583684	ENSP00000462617
ENST00000581417
ENST00000579687	ENSP00000462579
ENST00000583366	ENSP00000463945
ENST00000580011
ENST00000578313	ENSP00000464331
ENST00000584403
ENST00000578379	ENSP00000463199
ENST00000580389
ENST00000583186
ENST00000578892	ENSP00000464372
ENST00000579788	ENSP00000464665

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005178	integrin binding
GO:0005515	protein binding

Biological Process

GO:0016337	single organismal cell-cell adhesion
GO:0030198	extracellular matrix organization
GO:0050776	regulation of immune response

Cellular Component

GO:0001931	uropod
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome
GO:0071944	cell periphery

Orthologs

Species

Mus musculus

Gene ID

Gene Order

ENSMUSG00000001029

View Gene Order

Pathways

NETPATH

NetPath_24

TSLP pathway

REACTOME

REACT_11152

Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway

REACT_13552

Integrin cell surface interactions pathway

REACT_118779

Extracellular matrix organization pathway

REACT_75774

Adaptive Immune System pathway

REACT_6900

Immune System pathway

KEGG

hsa04514

Cell adhesion molecules (CAMs) pathway

hsa04650

Natural killer cell mediated cytotoxicity pathway

INOH

PID NCI

integrin2_pathway

Beta2 integrin cell surface interactions

Cross-References

SwissProt

TrEMBL

J3QQR8 J3QQX6 Q9NZC6

UniProt Splice Variant

Entrez Gene

3384

UniGene

RefSeq

NM_000873 NM_001099786 NM_001099787 NM_001099788 NM_001099789

HUGO

HGNC:5345

OMIM

146630

CCDS

CCDS11657

HPRD

00888

IMGT

EMBL

AC005803 AF212826

GenPept

AAF34580

RNA Seq Atlas

3384