Version 5.4
Homo sapiens Protein: ICAM2
Summary
InnateDB Protein IDBP-383427.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ICAM2
Protein Name intercellular adhesion molecule 2
Synonyms CD102;
Species Homo sapiens
Ensembl Protein ENSP00000388666
InnateDB Gene IDBG-64502 (ICAM2)
Protein Structure
UniProt Annotation
Function ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen- specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.
Subcellular Localization Membrane; Single-pass type I membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005178 integrin binding
Biological Process
GO:0016337 single organismal cell-cell adhesion
GO:0030198 extracellular matrix organization
GO:0050776 regulation of immune response
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR003987 Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal
IPR003988 Intercellular adhesion molecule
IPR013768 Intercellular adhesion molecule, N-terminal
PFAM PF03921
PRINTS PR01472
PR01473
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P13598
PhosphoSite PhosphoSite-P13598
TrEMBL Q9NZC6
UniProt Splice Variant
Entrez Gene 3384
UniGene
RefSeq NP_001093257
HUGO HGNC:5345
OMIM 146630
CCDS CCDS11657
HPRD 00888
IMGT
EMBL AB209878 AC005803 AF212826 AF340052 AF340053 AK223219 BC003097 CH471109 CR541812 CR541834 M32331 M32332 M32333 M32334 X15606
GenPept AAA36035 AAF34580 AAH03097 AAQ14909 AAQ14910 BAD93115 BAD96939 CAA33630 CAG46611 CAG46633 EAW94216

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca