Version 5.4
Bos taurus Gene: UBR5
Summary
InnateDB Gene IDBG-645050.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UBR5
Gene Name E3 ubiquitin-protein ligase UBR5
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000021209
Encoded Proteins
IDBP-697745
ubiquitin protein ligase E3 component n-recognin 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000104517:
This gene encodes a progestin-induced protein, which belongs to the HECT (homology to E6-AP carboxyl terminus) family. The HECT family proteins function as E3 ubiquitin-protein ligases, targeting specific proteins for ubiquitin-mediated proteolysis. This gene is localized to chromosome 8q22 which is disrupted in a variety of cancers. This gene potentially has a role in regulation of cell proliferation or differentiation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:64169832-64308334
Strand Forward strand
Band
Transcripts
ENSBTAT00000028262 ENSBTAP00000028262
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 66 interaction(s) predicted by orthology.
Predicted by orthology
Total 66 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0034450 ubiquitin-ubiquitin ligase activity
GO:0043130 ubiquitin binding
Biological Process
GO:0000209 protein polyubiquitination
GO:0006974 cellular response to DNA damage stimulus
GO:0033160 positive regulation of protein import into nucleus, translocation
GO:0035413 positive regulation of catenin import into nucleus
GO:0050847 progesterone receptor signaling pathway
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:1901315 negative regulation of histone H2A K63-linked ubiquitination
GO:2000780 negative regulation of double-strand break repair
Cellular Component
GO:0005634 nucleus
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000104517
View Gene Order
ENSMUSG00000037487
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04120
Ubiquitin mediated proteolysis pathway
mmu04120
Ubiquitin mediated proteolysis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F1N0L2
UniProt Splice Variant
Entrez Gene 515582
UniGene Bt.30209 Bt.89420
RefSeq NM_001192417 XM_005215566 XM_005215567
HUGO HGNC:16806
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02039335
GenPept
RNA Seq Atlas 515582

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca