Version 5.4
Homo sapiens Gene: UBR5
Summary
InnateDB Gene IDBG-31165.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UBR5
Gene Name ubiquitin protein ligase E3 component n-recognin 5
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000104517
Encoded Proteins
IDBP-31167
ubiquitin protein ligase E3 component n-recognin 5
IDBP-479178
ubiquitin protein ligase E3 component n-recognin 5
IDBP-476051
ubiquitin protein ligase E3 component n-recognin 5
IDBP-482594
ubiquitin protein ligase E3 component n-recognin 5
IDBP-480595
ubiquitin protein ligase E3 component n-recognin 5
IDBP-484888
ubiquitin protein ligase E3 component n-recognin 5
IDBP-480741
ubiquitin protein ligase E3 component n-recognin 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a progestin-induced protein, which belongs to the HECT (homology to E6-AP carboxyl terminus) family. The HECT family proteins function as E3 ubiquitin-protein ligases, targeting specific proteins for ubiquitin-mediated proteolysis. This gene is localized to chromosome 8q22 which is disrupted in a variety of cancers. This gene potentially has a role in regulation of cell proliferation or differentiation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:102253012-102412841
Strand Reverse strand
Band q22.3
Transcripts
ENST00000220959 ENSP00000220959
ENST00000520539 ENSP00000429084
ENST00000517465
ENST00000518205 ENSP00000428693
ENST00000521922 ENSP00000427819
ENST00000521767
ENST00000521312
ENST00000521566 ENSP00000428062
ENST00000519528
ENST00000520898 ENSP00000429127
ENST00000519365 ENSP00000428138
ENST00000518145
ENST00000522327
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 126 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 126 [view]
Protein-Protein 126 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0034450 ubiquitin-ubiquitin ligase activity
GO:0043130 ubiquitin binding
Biological Process
GO:0000209 protein polyubiquitination
GO:0006281 DNA repair
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006974 cellular response to DNA damage stimulus
GO:0008283 cell proliferation
GO:0016567 protein ubiquitination
GO:0033160 positive regulation of protein import into nucleus, translocation
GO:0035413 positive regulation of catenin import into nucleus
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0050847 progesterone receptor signaling pathway
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:1901315 negative regulation of histone H2A K63-linked ubiquitination
GO:2000780 negative regulation of double-strand break repair
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000037487
View Gene Order
ENSBTAG00000021209
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04120
Ubiquitin mediated proteolysis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.492445 Hs.737832
RefSeq NM_001282873 NM_015902 XM_005250956 XM_005250957 XM_005250959 XM_005250960 XM_005250962
HUGO
OMIM
CCDS CCDS34933 CCDS64946
HPRD 06436
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca