Version 5.4
Bos taurus Gene: TRIM63
Summary
InnateDB Gene IDBG-645236.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRIM63
Gene Name E3 ubiquitin-protein ligase TRIM63
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000005085
Encoded Proteins
IDBP-697928
E3 ubiquitin-protein ligase TRIM63
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 23438823
[Homo sapiens] TRIM63 was identified in a systematic screen for positive regulators of innate immune responses.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000158022:
This gene encodes a member of the RING zinc finger protein family found in striated muscle and iris. The product of this gene is an E3 ubiquitin ligase that localizes to the Z-line and M-line lattices of myofibrils. This protein plays an important role in the atrophy of skeletal and cardiac muscle and is required for the degradation of myosin heavy chain proteins, myosin light chain, myosin binding protein, and for muscle-type creatine kinase. [provided by RefSeq, Feb 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:127615050-127630608
Strand Forward strand
Band
Transcripts
ENSBTAT00000037900 ENSBTAP00000037722
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 82 interaction(s) predicted by orthology.
Predicted by orthology
Total 82 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0031432 titin binding
GO:0046872 metal ion binding
Biological Process
GO:0010468 regulation of gene expression
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0071549 cellular response to dexamethasone stimulus
Cellular Component
GO:0005622 intracellular
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000158022
View Gene Order
ENSMUSG00000028834
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL Q2KI94
UniProt Splice Variant
Entrez Gene 528912
UniGene Bt.57956
RefSeq NM_001046295 XM_005203183
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC112721 DAAA02006379 DAAA02006380
GenPept AAI12722
RNA Seq Atlas 528912

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca