InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PRL

Summary

InnateDB Gene

IDBG-64526.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRL

Gene Name

prolactin

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000172179

Encoded Proteins

IDBP-64528

prolactin

IDBP-809488

prolactin

IDBP-809493

prolactin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes the anterior pituitary hormone prolactin. This secreted hormone is a growth regulator for many tissues, including cells of the immune system. It may also play a role in cell survival by suppressing apoptosis, and it is essential for lactation. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:22287244-22297501

Strand

Reverse strand

Band

p22.3

Transcripts

ENST00000306482	ENSP00000302150
ENST00000617911	ENSP00000480195
ENST00000615510	ENSP00000478566

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005148	prolactin receptor binding
GO:0005179	hormone activity
GO:0005515	protein binding

Biological Process

GO:0007166	cell surface receptor signaling pathway
GO:0007565	female pregnancy
GO:0007595	lactation
GO:0008283	cell proliferation
GO:0040014	regulation of multicellular organism growth
GO:0046427	positive regulation of JAK-STAT cascade
GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway