Version 5.4
Homo sapiens Protein: PRL
Summary
InnateDB Protein IDBP-64528.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRL
Protein Name prolactin
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000302150
InnateDB Gene IDBG-64526 (PRL)
Protein Structure
UniProt Annotation
Function Prolactin acts primarily on the mammary gland by promoting lactation.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005148 prolactin receptor binding
GO:0005179 hormone activity
GO:0005515 protein binding
Biological Process
GO:0007166 cell surface receptor signaling pathway
GO:0007565 female pregnancy
GO:0007595 lactation
GO:0008283 cell proliferation
GO:0040014 regulation of multicellular organism growth
GO:0046427 positive regulation of JAK-STAT cascade
GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway
Cellular Component
GO:0005576 extracellular region
Protein Structure and Domains
PDB ID
InterPro IPR001400 Somatotropin hormone
IPR009079 Four-helical cytokine-like, core
PFAM PF00103
PRINTS PR00836
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P01236
PhosphoSite PhosphoSite-P01236
TrEMBL Q5THQ0
UniProt Splice Variant
Entrez Gene 5617
UniGene Hs.733249
RefSeq NP_001157030
HUGO HGNC:9445
OMIM 176760
CCDS CCDS4548
HPRD 07180
IMGT
EMBL BC015850 CH471087 D00411 GQ305133 M29386 U75583 V00566 X00540 X00541 X00543 X00544 X54393
GenPept AAA60173 AAB70858 AAH15850 ACT52574 BAA00312 CAA23829 CAA25214 CAA38263 CAA38264 EAW55435

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca