InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ARF4

Summary

InnateDB Gene

IDBG-645285.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARF4

Gene Name

ADP-ribosylation factor 4

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000016069

Encoded Proteins

IDBP-697987

ADP-ribosylation factor 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000168374:
This gene is a member of the human ARF gene family whose members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The gene products include 5 ARF proteins and 11 ARF-like proteins and constitute one family of the RAS superfamily. The ARF proteins are categorized as class I, class II and class III; this gene is a class II member. The members of each class share a common gene organization. The ARF4 gene spans approximately 12kb and contains six exons and five introns. This gene is the most divergent member of the human ARFs. Conflicting map positions at 3p14 or 3p21 have been reported for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 22:44150604-44169288

Strand

Forward strand

Band

Transcripts

ENSBTAT00000021386

ENSBTAP00000021386

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003924	GTPase activity
GO:0004871	signal transducer activity
GO:0005154	epidermal growth factor receptor binding
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0019001	guanyl nucleotide binding
GO:0031683	G-protein beta/gamma-subunit complex binding

Biological Process

GO:0006471	protein ADP-ribosylation
GO:0006810	transport
GO:0006886	intracellular protein transport
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007264	small GTPase mediated signal transduction
GO:0015031	protein transport
GO:0016192	vesicle-mediated transport
GO:0016477	cell migration
GO:0031584	activation of phospholipase D activity
GO:0043066	negative regulation of apoptotic process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:2000377	regulation of reactive oxygen species metabolic process

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0032587	ruffle membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000168374

View Gene Order

ENSMUSG00000021877

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_4

EGFR1 pathway

REACTOME

KEGG

INOH

PID NCI

erbb1_downstream_pathway

ErbB1 downstream signaling

Cross-References

SwissProt

Q3SZF2

TrEMBL

UniProt Splice Variant

Entrez Gene

518601

UniGene

RefSeq

NM_001034530

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC102895

GenPept

AAI02896

RNA Seq Atlas

518601