Homo sapiens Gene: ARF4
Summary
InnateDB Gene IDBG-41329.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARF4
Gene Name ADP-ribosylation factor 4
Synonyms ARF2;
Species Homo sapiens
Ensembl Gene ENSG00000168374
Encoded Proteins
ADP-ribosylation factor 4
ADP-ribosylation factor 4
ADP-ribosylation factor 4
ADP-ribosylation factor 4
ADP-ribosylation factor 4
ADP-ribosylation factor 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the human ARF gene family whose members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The gene products include 5 ARF proteins and 11 ARF-like proteins and constitute one family of the RAS superfamily. The ARF proteins are categorized as class I, class II and class III; this gene is a class II member. The members of each class share a common gene organization. The ARF4 gene spans approximately 12kb and contains six exons and five introns. This gene is the most divergent member of the human ARFs. Conflicting map positions at 3p14 or 3p21 have been reported for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:57571363-57598220
Strand Reverse strand
Band p14.3
Transcripts
ENST00000303436 ENSP00000306010
ENST00000496292 ENSP00000417501
ENST00000489843 ENSP00000475828
ENST00000486310 ENSP00000420655
ENST00000483848
ENST00000463880 ENSP00000420254
ENST00000493378
ENST00000495354
ENST00000488156 ENSP00000418388
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
Experimentally validated
Total 24 [view]
Protein-Protein 24 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0004871 signal transducer activity
GO:0005154 epidermal growth factor receptor binding
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0019001 guanyl nucleotide binding
GO:0031683 G-protein beta/gamma-subunit complex binding
Biological Process
GO:0006471 protein ADP-ribosylation
GO:0006886 intracellular protein transport
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007264 small GTPase mediated signal transduction
GO:0007420 brain development
GO:0015031 protein transport
GO:0016192 vesicle-mediated transport
GO:0016477 cell migration
GO:0031584 activation of phospholipase D activity
GO:0043066 negative regulation of apoptotic process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048678 response to axon injury
GO:2000377 regulation of reactive oxygen species metabolic process
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0032587 ruffle membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
EGFR1 pathway
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
ErbB1 downstream signaling
Cross-References
SwissProt
TrEMBL C9J6P1 C9JPM4
UniProt Splice Variant
Entrez Gene 378
UniGene Hs.652183
RefSeq NM_001660
HUGO HGNC:655
OMIM 601177
CCDS CCDS2884
HPRD 03107
IMGT
EMBL AC092418 AC114480
GenPept
RNA Seq Atlas 378