Bos taurus Gene: SPG21
Summary
InnateDB Gene IDBG-645311.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPG21
Gene Name Maspardin
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000011540
Encoded Proteins
Maspardin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000090487:
The protein encoded by this gene was identified by a two-hybrid screen using CD4 as the bait. It binds to the hydrophobic C-terminal amino acids of CD4 which are involved in repression of T cell activation. The interaction with CD4 is mediated by the noncatalytic alpha/beta hydrolase fold domain of this protein. It is thus proposed that this gene product modulates the stimulatory activity of CD4. At least three different transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:11853161-11873214
Strand Reverse strand
Band
Transcripts
ENSBTAT00000015332 ENSBTAP00000015332
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0042609 CD4 receptor binding
Biological Process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0030140 trans-Golgi network transport vesicle
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Cross-References
SwissProt Q8MJJ1
TrEMBL
UniProt Splice Variant
Entrez Gene 404069
UniGene Bt.1606 Bt.89986
RefSeq NM_205772
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AF451182 BC118320
GenPept AAI18321 AAM76998
RNA Seq Atlas 404069