Mus musculus Gene: Spg21
InnateDB Gene IDBG-177905.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Spg21
Gene Name spastic paraplegia 21 homolog (human)
Synonyms ACP33; BM-019; C78576; D9Wsu18e; GL010; MAST;
Species Mus musculus
Ensembl Gene ENSMUSG00000032388
Encoded Proteins
spastic paraplegia 21 homolog (human)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000090487:
The protein encoded by this gene was identified by a two-hybrid screen using CD4 as the bait. It binds to the hydrophobic C-terminal amino acids of CD4 which are involved in repression of T cell activation. The interaction with CD4 is mediated by the noncatalytic alpha/beta hydrolase fold domain of this protein. It is thus proposed that this gene product modulates the stimulatory activity of CD4. At least three different transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:65460937-65488470
Strand Forward strand
Band C
ENSMUST00000034955 ENSMUSP00000034955
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0042609 CD4 receptor binding
Biological Process
GO:0008150 biological_process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0030140 trans-Golgi network transport vesicle
Homo sapiens
Bos taurus
Gene ID
Gene Order
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
SwissProt Q9CQC8
UniProt Splice Variant
Entrez Gene 27965
UniGene Mm.272475
RefSeq NM_138584 XM_006511222
MGI ID MGI:106403
MGI Symbol Spg21
EMBL AK009332 AK011985 AK090017 AK149930 AK150215 AK150581 AK153284 AK170666 BC099434 BC132377 BC132403 CH466522
GenPept AAH99434 AAI32378 AAI32404 BAB26224 BAB27958 BAC41047 BAE29174 BAE29385 BAE29675 BAE31867 BAE41947 EDL26096
RNA Seq Atlas 27965