Version 5.4
Homo sapiens Gene: SPCS2
Summary
InnateDB Gene IDBG-64536.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPCS2
Gene Name signal peptidase complex subunit 2 homolog (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000118363
Encoded Proteins
IDBP-64538
signal peptidase complex subunit 2 homolog (S. cerevisiae)
IDBP-591911
signal peptidase complex subunit 2 homolog (S. cerevisiae)
IDBP-595460
signal peptidase complex subunit 2 homolog (S. cerevisiae)
IDBP-590050
signal peptidase complex subunit 2 homolog (S. cerevisiae)
IDBP-601515
signal peptidase complex subunit 2 homolog (S. cerevisiae)
IDBP-811701
signal peptidase complex subunit 2 homolog (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 11:74949247-74979031
Strand Forward strand
Band q13.4
Transcripts
ENST00000263672 ENSP00000263672
ENST00000530257 ENSP00000433439
ENST00000526361 ENSP00000434248
ENST00000532972 ENSP00000436759
ENST00000527290
ENST00000528265
ENST00000527225
ENST00000526883 ENSP00000434706
ENST00000610881 ENSP00000478550
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated
Total 13 [view]
Protein-Protein 11 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008233 peptidase activity
Biological Process
GO:0006412 translation
GO:0006465 signal peptide processing
GO:0006508 proteolysis
GO:0006614 SRP-dependent cotranslational protein targeting to membrane
GO:0010467 gene expression
GO:0044267 cellular protein metabolic process
GO:0050796 regulation of insulin secretion
Cellular Component
GO:0005787 signal peptidase complex
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000035227
View Gene Order
ENSBTAG00000006644
Not yet available
Pathways
NETPATH
REACTOME
REACT_19189
Synthesis, secretion, and deacylation of Ghrelin pathway
REACT_23824
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) pathway
REACT_24019
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) pathway
REACT_115902
SRP-dependent cotranslational protein targeting to membrane pathway
REACT_1014
Translation pathway
REACT_23974
Incretin synthesis, secretion, and inactivation pathway
REACT_17015
Metabolism of proteins pathway
REACT_160078
Peptide hormone metabolism pathway
REACT_71
Gene Expression pathway
KEGG
hsa03060
Protein export pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.715758
RefSeq NM_014752
HUGO
OMIM
CCDS CCDS44681
HPRD 15435
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca