Homo sapiens Gene: CLDN11
Summary
InnateDB Gene IDBG-64549.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CLDN11
Gene Name claudin 11
Synonyms OSP; OTM;
Species Homo sapiens
Ensembl Gene ENSG00000013297
Encoded Proteins
claudin 11
claudin 11
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a major component of central nervous system (CNS) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes. Mouse studies showed that the gene deficiency results in deafness and loss of the Sertoli cell epithelial phenotype in the testis. This protein is a tight junction protein at the human blood-testis barrier (BTB), and the BTB disruption is related to a dysfunction of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Aug 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:170418865-170860380
Strand Forward strand
Band q26.2
Transcripts
ENST00000064724 ENSP00000064724
ENST00000486975 ENSP00000417434
ENST00000486429
ENST00000489485
ENST00000468358
ENST00000471373
ENST00000477531
ENST00000488989
ENST00000480067
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0007155 cell adhesion
GO:0007283 spermatogenesis
GO:0008366 axon ensheathment
GO:0016338 calcium-independent cell-cell adhesion
Cellular Component
GO:0005886 plasma membrane
GO:0005923 tight junction
GO:0016021 integral component of membrane
GO:0045178 basal part of cell
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Tight junction interactions pathway
Cell-Cell communication pathway
Cell junction organization pathway
Cell-cell junction organization pathway
KEGG
Cell adhesion molecules (CAMs) pathway
Tight junction pathway
Leukocyte transendothelial migration pathway
Hepatitis C pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt O75508
TrEMBL B4DFI2
UniProt Splice Variant
Entrez Gene 5010
UniGene Hs.407600 Hs.599737
RefSeq NM_005602
HUGO HGNC:8514
OMIM 601326
CCDS CCDS3213
HPRD
IMGT
EMBL AC008041 AC026316 AC061708 AC092955 AC117446 AC117476 AF068863 AJ245901 AK294108 AK312923 BC013577 BT019402 BT019403 CH471052
GenPept AAC25187 AAH13577 AAV38209 AAV38210 BAG35768 BAG57443 CAB55487 EAW78505 EAW78509
RNA Seq Atlas 5010