Version 5.4
| Bos taurus Gene: SKP1 | |||||||
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| Summary | |||||||
| InnateDB Gene | IDBG-645796.3 | ||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||
| Gene Symbol | SKP1 | ||||||
| Gene Name | S-phase kinase-associated protein 1 | ||||||
| Synonyms | SKP1A | ||||||
| Species | Bos taurus | ||||||
| Ensembl Gene | ENSBTAG00000025191 | ||||||
| Encoded Proteins |
S-phase kinase-associated protein 1
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||
| Entrez Gene | |||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000113558:
This gene encodes a component of SCF complexes, which are composed of this protein, cullin 1, a ring-box protein, and one member of the F-box family of proteins. This protein binds directly to the F-box motif found in F-box proteins. SCF complexes are involved in the regulated ubiquitination of specific protein substrates, which targets them for degradation by the proteosome. Specific F-box proteins recognize different target protein(s), and many specific SCF substrates have been identified including regulators of cell cycle progression and development. Studies have also characterized the protein as an RNA polymerase II elongation factor. Alternative splicing of this gene results in two transcript variants. A related pseudogene has been identified on chromosome 7. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||
| Type | Protein coding | ||||||
| Genomic Location | Chromosome 7:47389357-47401412 | ||||||
| Strand | Reverse strand | ||||||
| Band | |||||||
| Transcripts |
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| Interactions | |||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 176 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathway Predictions based on Human Orthology Data | |||||||
| NETPATH |
Notch pathway
TGF_beta_Receptor pathway
TNFalpha pathway
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| REACTOME |
SCF-beta-TrCP mediated degradation of Emi1 pathway
Regulation of APC/C activators between G1/S and early anaphase pathway
SCF(Skp2)-mediated degradation of p27/p21 pathway
Cyclin A:Cdk2-associated events at S phase entry pathway
Cyclin E associated events during G1/S transition pathway
Cyclin D associated events in G1 pathway
Regulation of PLK1 Activity at G2/M Transition pathway
Antigen processing: Ubiquitination & Proteasome degradation pathway
Interleukin-1 signaling pathway
Prolactin receptor signaling pathway
Activation of NF-kappaB in B cells pathway
Nuclear signaling by ERBB4 pathway
Signaling by ERBB4 pathway
NOTCH1 Intracellular Domain Regulates Transcription pathway
Degradation of beta-catenin by the destruction complex pathway
Circadian Clock pathway
Vpu mediated degradation of CD4 pathway
Constitutive Signaling by NOTCH1 PEST Domain Mutants pathway
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling pathway
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants pathway
truncated APC mutants destabilize the destruction complex pathway
G1 Phase pathway
AXIN mutants destabilize the destruction complex, activating WNT signaling pathway
APC truncation mutants are not K63 polyubiquitinated pathway
Signaling by Hedgehog pathway
AMER1 mutants destabilize the destruction complex pathway
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
Signaling by WNT in cancer pathway
APC/C-mediated degradation of cell cycle proteins pathway
AXIN missense mutants destabilize the destruction complex pathway
Regulation of mitotic cell cycle pathway
Signaling by Wnt pathway
Mitotic G1-G1/S phases pathway
Signaling by NOTCH1 in Cancer pathway
Cytokine Signaling in Immune system pathway
S Phase pathway
APC truncation mutants have impaired AXIN binding pathway
Degradation of GLI2 by the proteasome pathway
GLI3 is processed to GLI3R by the proteasome pathway
T41 mutants of beta-catenin aren't phosphorylated pathway
Degradation of GLI1 by the proteasome pathway
FBXW7 Mutants and NOTCH1 in Cancer pathway
G1/S Transition pathway
Signal Transduction pathway
Hedgehog 'off' state pathway
misspliced GSK3beta mutants stabilize beta-catenin pathway
S45 mutants of beta-catenin aren't phosphorylated pathway
deletions in the AMER1 gene destabilize the destruction complex pathway
Cell Cycle pathway
Adaptive Immune System pathway
Immune System pathway
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
S33 mutants of beta-catenin aren't phosphorylated pathway
truncations of AMER1 destabilize the destruction complex pathway
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex pathway
Signaling by Interleukins pathway
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
Signaling by NOTCH pathway
G2/M Transition pathway
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling pathway
Signaling by NOTCH1 pathway
Cell Cycle, Mitotic pathway
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
TCF7L2 mutants don't bind CTBP pathway
HIV Infection pathway
Class I MHC mediated antigen processing & presentation pathway
Mitotic G2-G2/M phases pathway
Host Interactions of HIV factors pathway
Signaling by the B Cell Receptor (BCR) pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
S37 mutants of beta-catenin aren't phosphorylated pathway
Disease pathway
Nuclear signaling by ERBB4 pathway
G2/M Transition pathway
Signaling by the B Cell Receptor (BCR) pathway
Cell Cycle, Mitotic pathway
Class I MHC mediated antigen processing & presentation pathway
G1 Phase pathway
Disease pathway
deletions in the AMER1 gene destabilize the destruction complex pathway
Signaling by Wnt pathway
Prolactin receptor signaling pathway
Hedgehog 'off' state pathway
Signaling by WNT in cancer pathway
Cyclin A:Cdk2-associated events at S phase entry pathway
Signaling by ERBB4 pathway
Degradation of beta-catenin by the destruction complex pathway
Cytokine Signaling in Immune system pathway
AMER1 mutants destabilize the destruction complex pathway
Cell Cycle pathway
APC/C-mediated degradation of cell cycle proteins pathway
Immune System pathway
SCF-beta-TrCP mediated degradation of Emi1 pathway
AXIN mutants destabilize the destruction complex, activating WNT signaling pathway
Cyclin D associated events in G1 pathway
T41 mutants of beta-catenin aren't phosphorylated pathway
Constitutive Signaling by NOTCH1 PEST Domain Mutants pathway
APC truncation mutants have impaired AXIN binding pathway
Antigen processing: Ubiquitination & Proteasome degradation pathway
Mitotic G2-G2/M phases pathway
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex pathway
Regulation of APC/C activators between G1/S and early anaphase pathway
Activation of NF-kappaB in B cells pathway
Degradation of GLI2 by the proteasome pathway
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling pathway
Signaling by NOTCH1 pathway
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
Regulation of mitotic cell cycle pathway
Degradation of GLI1 by the proteasome pathway
S37 mutants of beta-catenin aren't phosphorylated pathway
AXIN missense mutants destabilize the destruction complex pathway
GLI3 is processed to GLI3R by the proteasome pathway
Signaling by NOTCH1 in Cancer pathway
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
FBXW7 Mutants and NOTCH1 in Cancer pathway
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
G1/S Transition pathway
Signaling by Interleukins pathway
APC truncation mutants are not K63 polyubiquitinated pathway
S45 mutants of beta-catenin aren't phosphorylated pathway
Regulation of PLK1 Activity at G2/M Transition pathway
Mitotic G1-G1/S phases pathway
misspliced GSK3beta mutants stabilize beta-catenin pathway
TCF7L2 mutants don't bind CTBP pathway
Adaptive Immune System pathway
truncations of AMER1 destabilize the destruction complex pathway
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling pathway
NOTCH1 Intracellular Domain Regulates Transcription pathway
Signaling by Hedgehog pathway
Interleukin-1 signaling pathway
Cyclin E associated events during G1/S transition pathway
Signal Transduction pathway
truncated APC mutants destabilize the destruction complex pathway
Signaling by NOTCH pathway
SCF(Skp2)-mediated degradation of p27/p21 pathway
S33 mutants of beta-catenin aren't phosphorylated pathway
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
S Phase pathway
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| KEGG |
Wnt signaling pathway pathway
TGF-beta signaling pathway pathway
Cell cycle pathway
Ubiquitin mediated proteolysis pathway
Circadian rhythm pathway
Oocyte meiosis pathway
Protein processing in endoplasmic reticulum pathway
Ubiquitin mediated proteolysis pathway
TGF-beta signaling pathway pathway
Wnt signaling pathway pathway
Cell cycle pathway
Circadian rhythm pathway
Oocyte meiosis pathway
Protein processing in endoplasmic reticulum pathway
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| INOH |
IL-1 signaling pathway pathway
Toll-like receptor signaling pathway pathway
Wnt signaling pathway pathway
Hedgehog signaling pathway pathway
IL-1 signaling pathway pathway
Toll-like receptor signaling pathway pathway
Wnt signaling pathway pathway
Hedgehog signaling pathway pathway
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| PID NCI |
Regulation of nuclear beta catenin signaling and target gene transcription
Degradation of beta catenin
Notch signaling pathway
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| Cross-References | |||||||
| SwissProt | Q3ZCF3 | ||||||
| TrEMBL | |||||||
| UniProt Splice Variant | |||||||
| Entrez Gene | 615427 | ||||||
| UniGene | Bt.64572 Bt.87240 | ||||||
| RefSeq | NM_001034781 | ||||||
| HUGO | |||||||
| OMIM | |||||||
| CCDS | |||||||
| HPRD | |||||||
| IMGT | |||||||
| EMBL | BC102435 BT029901 | ||||||
| GenPept | AAI02436 ABM06147 | ||||||
| RNA Seq Atlas | 615427 | ||||||